Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer

  • Authors:
    • Leena‑Maija Soveri
    • Pia Österlund
    • Tarja Ruotsalainen
    • Tuija Poussa
    • Hilpi Rautelin
    • Petri Bono
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  • Published online on: November 29, 2013     https://doi.org/10.3892/ol.2013.1714
  • Pages: 553-559
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Abstract

5‑Fluorouracil (5‑FU)‑based chemotherapy is the mainstay of adjuvant treatment for colorectal cancer (CRC). Few studies have explored Helicobacter pylori (H. pylori)‑associated gastrointestinal symptoms in the diagnosis of CRC, and the association between H. pylori infection and gastrointestinal toxicity during adjuvant chemotherapy in CRC. Seventy‑nine CRC patients were randomised in a prospective clinical trial to receive 5‑FU and leucovorin administered as bolus injection (Mayo regimen) or continuous infusion (simplified de Gramont regimen). H. pylori antibodies were analysed at baseline, twice monthly during treatment and after treatment up to 12 months. Thirty‑seven patients (47%) were H. pylori‑seronegative at baseline. There was no significant association between baseline H. pylori seropositivity (n=42; 53%) and oro‑gastrointestinal toxicity during chemotherapy. The median time from symptom onset of CRC to surgery was significantly longer in patients with H. pylori infection (median time, 6 vs. 5 months; P=0.012). Functional dyspeptic symptoms at presentation significantly delayed diagnosis (median time, 7.5 vs. 5 months; P=0.035), whereas anaemia, bowel symptoms, occlusion, blood in the stool, infection and hypolactasia did not. We conclude that there is no association between H. pylori status and gastrointestinal toxicity in CRC patients during chemotherapy. Dyspeptic symptoms and presence of H. pylori may delay the diagnosis of CRC. (www.controlled‑trials.com/ISRCTN98405441).
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2014-February
Volume 7 Issue 2

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Spandidos Publications style
Soveri LM, Österlund P, Ruotsalainen T, Poussa T, Rautelin H and Bono P: Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer. Oncol Lett 7: 553-559, 2014.
APA
Soveri, L., Österlund, P., Ruotsalainen, T., Poussa, T., Rautelin, H., & Bono, P. (2014). Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer. Oncology Letters, 7, 553-559. https://doi.org/10.3892/ol.2013.1714
MLA
Soveri, L., Österlund, P., Ruotsalainen, T., Poussa, T., Rautelin, H., Bono, P."Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer". Oncology Letters 7.2 (2014): 553-559.
Chicago
Soveri, L., Österlund, P., Ruotsalainen, T., Poussa, T., Rautelin, H., Bono, P."Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer". Oncology Letters 7, no. 2 (2014): 553-559. https://doi.org/10.3892/ol.2013.1714