α‑smooth muscle actin‑positive fibroblasts correlate with poor survival in hepatocellular carcinoma
- Authors:
- Jignesh G. Parikh
- Anand Kulkarni
- Cameila Johns
View Affiliations
Affiliations: Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
- Published online on: November 29, 2013 https://doi.org/10.3892/ol.2013.1720
-
Pages:
573-575
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Abstract
The current case‑control study was conducted to assess the value of activated fibroblasts with high α‑smooth muscle actin (α‑SMA) expression as an indicator of survival in hepatocellular carcinoma (HCC) patients. In total, 47 patients diagnosed with HCC who underwent a liver biopsy at the Veterans Affairs Medical Center (Memphis, TN, USA) between January 2000 and December 2009, and 10 age‑ and gender‑matched controls with normal liver biopsy samples were included in the study. The immunohistochemical staining for α‑SMA was performed and classified qualitatively and quantitatively within tumor stroma and perisinusoidal spaces. HCC patients with high qualitative and quantitative expression of α‑SMA revealed a statistically significant negative correlation with 3‑year [odds ratio (OR), 0.021 and 0.111; P=0.001 and 0.0302, respectively] and 1.5‑year (OR, 0.040 and 0.051; P=0.0330 and 0.0492, respectively) survival rates in comparison with low expression. The results of the present study demonstrated a predictive role of high qualitative and quantitative expression in activated fibroblasts for poor survival in patients with HCC.
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