Mucinous carcinoma occurring in the male breast

Ishida,Mitsuaki; Umeda,Tomoko; Kawai,Yuki; Mori,Tsuyoshi; Kubota,Yoshihiro; Abe,Hajime; Iwai,Muneo; Yoshida,Keiko; Kagotani,Akiko; Tani,Tohru; Okabe,Hidetoshi

doi:10.3892/ol.2013.1730

Mucinous carcinoma occurring in the male breast

Authors:
- Mitsuaki Ishida
- Tomoko Umeda
- Yuki Kawai
- Tsuyoshi Mori
- Yoshihiro Kubota
- Hajime Abe
- Muneo Iwai
- Keiko Yoshida
- Akiko Kagotani
- Tohru Tani
- Hidetoshi Okabe
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Affiliations: Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan, Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan
Published online on: December 5, 2013 https://doi.org/10.3892/ol.2013.1730
Pages: 378-380

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Abstract

Male breast carcinoma is an uncommon neoplasm, accounting for 0.6% of all breast carcinomas. Invasive ductal carcinoma of no special type is the most common type of male breast carcinoma, and mucinous carcinoma occurring in the male breast is extremely rare. In the present study, we report a case of mucinous carcinoma of the male breast and discuss the clinicopathological features of this type of tumor. A 63‑year‑old Japanese male presented with a gradually enlarged nodule in the right breast. The resected breast specimen revealed pure mucinous carcinoma and immunohistochemical analyses demonstrated that tumor cells were positive for estrogen receptor (ER), but negative for progesterone receptor (PgR). In addition, HER2 expression was not amplified. Pure mucinous carcinoma is generally associated with a low incidence of lymph node or distant metastases, and excellent disease‑free survival in females. However, certain cases of this type of tumor with axillary lymph node metastasis in the male breast have been reported. In addition, the immunoprofiles of mucinous carcinoma in males are fundamentally the same as those in females. More than 90% of cases show positive immunoreactivity for ER and/or PgR, and HER2 expression is not amplified. However, it has been reported that breast cancer in males is more frequently positive for ER than in females, and has less HER2 overexpression. The high rate of hormone receptor‑positive breast cancer in males is considered to be due to similar conditions as those in breast cancer in postmenopausal women. The pathogenesis of male breast carcinoma, including mucinous carcinoma, remains unclear; therefore, additional clinicopathological studies are required.

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