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Article

MicroRNA‑23a promotes neuroblastoma cell metastasis by targeting CDH1

  • Authors:
    • Lin Cheng
    • Tao Yang
    • Yongqin Kuang
    • Bin Kong
    • Sixun Yu
    • Haifeng Shu
    • Hutian Zhou
    • Jianwen Gu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China
  • Pages: 839-845
    |
    Published online on: January 14, 2014
       https://doi.org/10.3892/ol.2014.1794
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Abstract

CDH1 inactivation is important in tumor metastasis. In the present study, it was suggested that the mRNA and protein levels of CDH1 decreased in metastatic neuroblastoma (NB) tissues compared with those in primary NB tissues. The aim of the study was to explore the regulatory mechanisms of CDH1 downregulation in metastatic NB. MicroRNAs are small non‑coding RNAs (~22 nt in length) that negatively regulate target mRNAs and are involved in various cancer‑related processes, including metastasis. In the current study, miR‑23a was shown to be upregulated in human metastatic NB tissues compared with primary NB tissues. Inhibition of miR‑23a may significantly suppress NB cell migration and invasion. In vitro reporter assay suggested that CDH1 is a direct target gene of miR‑23a. Furthermore, blocking the expression of miR‑23a partly restored the expression of CDH1 in NB cells. These findings provide evidence that miR‑23a is key in promoting NB cell migration and invasion through targeting CDH1, and suggest that exogenous miR‑23a may have therapeutic value in treating NB metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng L, Yang T, Kuang Y, Kong B, Yu S, Shu H, Zhou H and Gu J: MicroRNA‑23a promotes neuroblastoma cell metastasis by targeting CDH1. Oncol Lett 7: 839-845, 2014.
APA
Cheng, L., Yang, T., Kuang, Y., Kong, B., Yu, S., Shu, H. ... Gu, J. (2014). MicroRNA‑23a promotes neuroblastoma cell metastasis by targeting CDH1. Oncology Letters, 7, 839-845. https://doi.org/10.3892/ol.2014.1794
MLA
Cheng, L., Yang, T., Kuang, Y., Kong, B., Yu, S., Shu, H., Zhou, H., Gu, J."MicroRNA‑23a promotes neuroblastoma cell metastasis by targeting CDH1". Oncology Letters 7.3 (2014): 839-845.
Chicago
Cheng, L., Yang, T., Kuang, Y., Kong, B., Yu, S., Shu, H., Zhou, H., Gu, J."MicroRNA‑23a promotes neuroblastoma cell metastasis by targeting CDH1". Oncology Letters 7, no. 3 (2014): 839-845. https://doi.org/10.3892/ol.2014.1794
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng L, Yang T, Kuang Y, Kong B, Yu S, Shu H, Zhou H and Gu J: MicroRNA‑23a promotes neuroblastoma cell metastasis by targeting CDH1. Oncol Lett 7: 839-845, 2014.
APA
Cheng, L., Yang, T., Kuang, Y., Kong, B., Yu, S., Shu, H. ... Gu, J. (2014). MicroRNA‑23a promotes neuroblastoma cell metastasis by targeting CDH1. Oncology Letters, 7, 839-845. https://doi.org/10.3892/ol.2014.1794
MLA
Cheng, L., Yang, T., Kuang, Y., Kong, B., Yu, S., Shu, H., Zhou, H., Gu, J."MicroRNA‑23a promotes neuroblastoma cell metastasis by targeting CDH1". Oncology Letters 7.3 (2014): 839-845.
Chicago
Cheng, L., Yang, T., Kuang, Y., Kong, B., Yu, S., Shu, H., Zhou, H., Gu, J."MicroRNA‑23a promotes neuroblastoma cell metastasis by targeting CDH1". Oncology Letters 7, no. 3 (2014): 839-845. https://doi.org/10.3892/ol.2014.1794
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