CD30+ extranodal natural killer/T‑cell lymphoma mimicking phlegmonous myositis: A case report

Yang,Yan‑Jia; Li,Ya‑Xin; Liu,Yan‑Bin; Yang,Mei; Liu,Kai

doi:10.3892/ol.2014.1924

CD30+ extranodal natural killer/T‑cell lymphoma mimicking phlegmonous myositis: A case report

Authors:
- Yan‑Jia Yang
- Ya‑Xin Li
- Yan‑Bin Liu
- Mei Yang
- Kai Liu
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Affiliations: Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
Published online on: February 28, 2014 https://doi.org/10.3892/ol.2014.1924
Pages: 1419-1421

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Abstract

The current study presents a case of a 23‑year‑old male with CD30+ nasal‑type extranodal natural killer/T‑cell lymphoma (NKTL), with unusual clinical features mimicking phlegmonous myositis. The patient initially presented with swelling and tenderness of the left lower limb, particularly around the left ankle. One month later, pharyngalgia and fever developed and the patient was treated with antibiotics for the phlegmonous inflammation, however, the symptoms were not relieved. A muscle biopsy was performed on the lesion and revealed diffuse infiltration of atypical lymphoid cells with irregular nuclei. Immunohistochemistry showed staining for CD3ε(‑), CD20(‑), CD45(+), CD30(+) and CD56(+) presented with positive staining for certain tumor cells, granzyme B(+), activin receptor‑like kinase 1(‑), Ki‑67(+) and Epstein‑Barr virus‑encoded small RNA(+), which indicated nasal‑type extranodal NKTL. The present case emphasized that extranodal NKTL may be a rare cause of phlegmonous inflammation and fever of undetermined origin.

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