Mixed lineage leukemia‑septin 5 fusion transcript in de novo adult acute myeloid leukemia with t(11;22)(q23;q11.2): A case report
- Authors:
- Wen Gao
- Tong Wang
- Yin Wu
- Hong Xing Liu
- Yan Chen Li
- Wen Ming Chen
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Affiliations: Department of Hematology, Myeloma Research Center of Beijing, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China, Center of Lu Dao‑Pei Hematology·Neoplasm, He‑Bei Yan Da Hospital, Langfang, Hebei 065201, P.R. China, Center of Lu Dao‑Pei Hematology·Neoplasm, He‑Bei Yan Da Hospital, Langfang, Hebei 065201, P.R. China
- Published online on: March 14, 2014 https://doi.org/10.3892/ol.2014.1971
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1930-1932
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Abstract
The current report presents a case of de novo acute myeloid leukemia (AML) in a 32‑year‑old male. Cytogenetic analysis showed that the karyotype of the bone marrow cells was as follows: 46,XY,t(11;22)(q23;q11.2)[13]/46,X,‑Y,+10,t(11;22)(q23;q11.2)[7]/47,XY,+10,t(11;22)(q23;q11.2)[1]/46,XY[1]. Fluorescence in situ hybridization analysis using a mixed lineage leukemia (MLL)‑specific probe showed a split in the MLL gene. Reverse transcription polymerase chain reaction (PCR) analysis demonstrated an MLL‑septin 5 (SEPT5) fusion transcript in the patient. Nucleotide sequencing analysis of the PCR product confirmed the fusion between the MLL exon 9 and SEPT5 exon 3, and the product was 521 bp in length. The present study reviewed the clinical and molecular features of the AML with an MLL‑SEPT5 fusion gene.
View References
|
1
|
Pui CH, Kane JR and Crist WM: Biology and
treatment of infant leukemias. Leukemia. 9:762–769. 1995.PubMed/NCBI
|
|
2
|
Balgobind BV, Raimondi SC, Harbott J, et
al: Novel prognostic subgroups in childhood 11q23/MLL-rearranged
acute myeloid leukemia: results of an international retrospective
study. Blood. 114:2489–2496. 2009. View Article : Google Scholar
|
|
3
|
Meyer C, Schneider B, Jakob S, et al: The
MLL recombinome of acute leukemias. Leukemia. 20:777–784. 2006.
View Article : Google Scholar
|
|
4
|
Meyer C, Kowarz E, Hofmann J, et al: New
insights to the MLL recombinome of acute leukemias. Leukemia.
23:1490–1499. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Cerveira N, Bizarro S and Teixeira MR:
MLL-SEPTIN gene fusions in hematological malignancies. Biol Chem.
392:713–724. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Launay E, Henry C, Meyer C, et al:
MLL-SEPT5 fusion transcript in infant acute myeloid leukemia with
t(11;22)(q23;q11). Leuk Lymphoma. Jun 3–2013.(Epub ahead of
print).
|
|
7
|
Abdou SM, Jadayel DM, Min T, et al:
Incidence of MLL rearrangement in acute myeloid leukemia, and a
CALM-AF10 fusion in M4 type acute myeloblastic leukemia. Leuk
Lymphoma. 43:89–95. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Tatsumi K, Taki T, Taniwaki M, et al: The
CDCREL1 gene fused to MLL in de novo acute myeloid
leukemia with t(11;22)(q23;q11.2) and its frequent expression in
myeloid leukemia cell lines. Genes Chromosomes Cancer. 30:230–235.
2001.
|
|
9
|
Megonigal MD, Rappaport EF, Jones DH, et
al: t(11;22)(q23;q11.2) in acute myeloid leukemia of infant twins
fuses MLL with hCDCrel, a cell division cycle gene in the genomic
region of deletion in DiGeorge and velocardiofacial syndromes. Proc
Natl Acad Sci USA. 11:6413–6418. 1998. View Article : Google Scholar
|
|
10
|
Baer MR, Stewart CC, Lawrence D, et al:
Acute myeloid leukemia with 11q23 translocations: myelomonocytic
immunophenotype by multiparameter flow cytometry. Leukemia.
12:317–325. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Marukawa O, Akao Y, Inazawa J, et al:
Molecular cloning of the breakpoint of t(11;22) (q23;q11)
chromosome translocation in an adult acute myelomonocytic
leukaemia. Br J Haematol. 92:687–691. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Kobayashi H, Miyachi H, Ogawa T and Jimbo
M: Translocation t(11;22)(q23;q11) in an adult with acute
monoblastic leukemia. Jpn J Med. 29:527–532. 1990. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Shaffer LG, Slovak ML and Campbell LJ: An
International System for Human Cytogenetic Nomenclature. S. Karger;
Basel: pp. 1382009
|
