Primary testicular lymphoma with subcutaneous masses as the sole manifestation of the first relapse and central nervous system lymphoma as the second relapse: A case report and literature review

Du,Zunguo; Wang,Yin; Zhu,Ping; Leng,Haiyan; Tang,Feng; Xu,Xiaoping; Chen,Zi

doi:10.3892/ol.2014.2052

Primary testicular lymphoma with subcutaneous masses as the sole manifestation of the first relapse and central nervous system lymphoma as the second relapse: A case report and literature review

Authors:
- Zunguo Du
- Yin Wang
- Ping Zhu
- Haiyan Leng
- Feng Tang
- Xiaoping Xu
- Zi Chen
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Affiliations: Department of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Neuropathology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
Published online on: April 9, 2014 https://doi.org/10.3892/ol.2014.2052
Pages: 1881-1884

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Abstract

Primary testicular lymphoma (PTL) accounts for ~1% of all non‑Hodgkin's lymphomas and has a marked tendency for systemic relapse. The current study presents a unique case of testicular diffuse large B‑cell lymphoma of non‑germinal center B‑cell subtype, with subcutaneous masses as the sole manifestation of the first relapse and central nervous system lymphoma as the second relapse. Subcutaneous relapse and subsequent brain relapse are extremely rare signs of PTL dissemination. The patient received methotrexate‑based combined chemotherapy and achieved a partial response. This case presents a rare pattern of treatment failure in this malignant clinical entity.

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