Peripheral primitive neuroectodermal tumor of the parotid gland in a child: A case report

Wang,Xing; Meng,Jian

doi:10.3892/ol.2014.2156

Peripheral primitive neuroectodermal tumor of the parotid gland in a child: A case report

Authors:
- Xing Wang
- Jian Meng
View Affiliations

Affiliations: Department of Stomatology, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou, Jiangsu 221000, P.R. China, Department of Dentistry, Central Hospital of Xuzhou City, Xuzhou, Jiangsu 221009, P.R. China
Published online on: May 19, 2014 https://doi.org/10.3892/ol.2014.2156
Pages: 745-747

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Primitive neuroectodermal tumor (PNET) is a term used to describe a group of highly malignant neoplasms of soft‑tissue origin, with varying degrees of divergent differentiation. The occurrence of peripheral PNET in the head and neck region has been reported infrequently in the medical literature. This disease generally occurs in adolescents and young adults, and rarely occurs in children <3 years old. The current study presents an extremely rare case of pPNET of the parotid gland in a 2‑year‑old male, which had been previously misdiagnosed and treated as a mumps. The lesion showed the characteristic histological features of pleomorphic cellular infiltrate with hyperchromatic small cells scattered in the fibrovascular stroma, interposed by fibrous septa and Homer‑Wright rosettes. Positive immunohistochemical staining for CD99 and vimentin was detected. The patient was treated with chemotherapy and radiotherapy following surgical removal, and has been under close observation since the treatment (approximately seven months), with no signs of recurrence. The clinical history and radiological and histopathological findings are presented, together with the immunoreactivity of this tumor.

View Figures

View References

1	Stout AP: A tumor of the ulnar nerve. Proc NY Pathol Soc. 18:2–11. 1918.
2	Desai SS and Jambhekar NA: Pathology of Ewing’s sarcoma/PNET: Current opinion and emerging concepts. Indian J Orthop. 44:363–368. 2010.
3	Tazi I, Zafad S, Madani A, et al: Askin tumor: a case report with literature review. Cancer Radiother. 13:771–774. 2009.(In French).
4	Song HC, Sun N, Zhang WP and Huang CR: Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the urogenital tract in children. Chin Med J (Engl). 125:932–936. 2012.
5	Heikaus S, Schaefer KL, Eucker J, et al: Primary primitive neuroectodermal tumor/Ewing’s tumor of the testis in a 46-year-old man-differential diagnosis and review of the literature. Hum Pathol. 40:893–897. 2009.
6	Hormozi AK, Ghazisaidi MR and Hosseini SN: Unusual presentation of peripheral primitive neuroectodermal tumor of the maxilla. J Craniofac Surg. 21:1761–1763. 2010.
7	Nikitakis NG, Salama AR, O’Malley BW Jr, et al: Malignant peripheral primitive neuroectodermal tumor-peripheral neuroepithelioma of the head and neck: a clinicopathologic study of five cases and review of the literature. Head Neck. 25:488–498. 2003.
8	Helsel JC, Mrak RE, Hanna E, et al: Peripheral primitive neuroectodermal tumor of the parotid gland region: report of a case with fine-needle aspiration findings. Diagn Cytopathol. 22:161–166. 2000.
9	Hviid A, Rubin S and Mühlemann K: Mumps. Lancet. 371:932–944. 2008.
10	Brazão-Silva MT, Fernandes AV, Faria PR, et al: Ewing’s sarcoma of the mandible in a young child. Braz Dent J. 21:74–79. 2010.
11	Ibarburen C, Haberman JJ and Zerhouni EA: Peripheral primitive neuroectodermal tumors. CT and MRI evaluation. Eur J Radiol. 21:225–232. 1996.
12	Lawlor ER, Mathers JA, Bainbridge T, et al: Peripheral primitive neuroectodermal tumors in adults: documentation by molecular analysis. J Clin Oncol. 16:1150–1157. 1998.
13	Windfuhr JP: Primitive neuroectodermal tumor of the head and neck: incidence, diagnosis, and management. Ann Otol Rhinol Laryngol. 113:533–543. 2004.
14	Talesh KT, Motamedi MH and Jeihounian M: Ewing’s sarcoma of the mandibular condyle: report of a case. J Oral Maxillofac Surg. 61:1216–1219. 2003.
15	Schmidt D, Harms D and Burdach S: Malignant peripheral neuroectodermal tumours of childhood and adolescence. Virchows Arch A Pathol Anat Histopathol. 406:351–365. 1985.
16	Dehner LP: Primitive neuroectodermal tumor and Ewing’s sarcoma. Am J Surg Pathol. 17:1–13. 1993.
17	Fontaine C, Schots R, Braeckman J, et al: Long-term survival in an adult metastatic renal peripheral primitive neuroectodermal tumor (PPNET) with multimodality treatment including high-dose chemotherapy. Ann Oncol. 8:691–694. 1997.
18	Jairam V, Roberts KB and Yu JB: Historical trends in the use of radiation therapy for pediatric cancers: 1973–2008. Int J Radiat Oncol Biol Phys. 85:e151–e155. 2013.