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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-2014 Volume 8 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Case Report Open Access

Lung adenocarcinoma harboring L858R and T790M mutations in epidermal growth factor receptor, with poor response to gefitinib: A case report

  • Authors:
    • Yue Feng Wang
    • Xianhong Xiang
    • Xiaojuan Pei
    • Shuhua  Li
    • Cuilan Tang
    • Liantang Wang
    • Zun‑Fu Ke
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Interventional Radiology, Huizhou Municipal Central Hospital, Huizhou, Guangdong 516001, P.R. China, Department of Pathology, Huizhou Municipal Central Hospital, Huizhou, Guangdong 516001, P.R. China
  • Pages: 1039-1042
    |
    Published online on: July 4, 2014
       https://doi.org/10.3892/ol.2014.2321
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Abstract

Lung cancer is the leading cause of mortality among malignant diseases in humans worldwide. During the last decade, molecular targeted therapies for non‑small cell lung cancer using first‑generation, reversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), including gefitinib, have been shown to be a promising approach for patients harboring activating mutations in EGFR. The current study reports a 77‑year‑old patient diagnosed with adenocarcinoma harboring L858R and T790M point mutations in the EGFR gene. The patient was treated with gefitinib as the second‑line therapy, but no clinical benefit was observed. As the majority of patients with lung cancer receiving EGFR‑TKI therapy acquire resistance, repeated biopsies and detection of the EGFR mutation state are beneficial for selecting appropriate treatments.
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Copy and paste a formatted citation
Spandidos Publications style
Wang YF, Xiang X, Pei X, Li S, Tang C, Wang L and Ke ZF: Lung adenocarcinoma harboring L858R and T790M mutations in epidermal growth factor receptor, with poor response to gefitinib: A case report. Oncol Lett 8: 1039-1042, 2014.
APA
Wang, Y.F., Xiang, X., Pei, X., Li, S., Tang, C., Wang, L., & Ke, Z. (2014). Lung adenocarcinoma harboring L858R and T790M mutations in epidermal growth factor receptor, with poor response to gefitinib: A case report. Oncology Letters, 8, 1039-1042. https://doi.org/10.3892/ol.2014.2321
MLA
Wang, Y. F., Xiang, X., Pei, X., Li, S., Tang, C., Wang, L., Ke, Z."Lung adenocarcinoma harboring L858R and T790M mutations in epidermal growth factor receptor, with poor response to gefitinib: A case report". Oncology Letters 8.3 (2014): 1039-1042.
Chicago
Wang, Y. F., Xiang, X., Pei, X., Li, S., Tang, C., Wang, L., Ke, Z."Lung adenocarcinoma harboring L858R and T790M mutations in epidermal growth factor receptor, with poor response to gefitinib: A case report". Oncology Letters 8, no. 3 (2014): 1039-1042. https://doi.org/10.3892/ol.2014.2321
Copy and paste a formatted citation
x
Spandidos Publications style
Wang YF, Xiang X, Pei X, Li S, Tang C, Wang L and Ke ZF: Lung adenocarcinoma harboring L858R and T790M mutations in epidermal growth factor receptor, with poor response to gefitinib: A case report. Oncol Lett 8: 1039-1042, 2014.
APA
Wang, Y.F., Xiang, X., Pei, X., Li, S., Tang, C., Wang, L., & Ke, Z. (2014). Lung adenocarcinoma harboring L858R and T790M mutations in epidermal growth factor receptor, with poor response to gefitinib: A case report. Oncology Letters, 8, 1039-1042. https://doi.org/10.3892/ol.2014.2321
MLA
Wang, Y. F., Xiang, X., Pei, X., Li, S., Tang, C., Wang, L., Ke, Z."Lung adenocarcinoma harboring L858R and T790M mutations in epidermal growth factor receptor, with poor response to gefitinib: A case report". Oncology Letters 8.3 (2014): 1039-1042.
Chicago
Wang, Y. F., Xiang, X., Pei, X., Li, S., Tang, C., Wang, L., Ke, Z."Lung adenocarcinoma harboring L858R and T790M mutations in epidermal growth factor receptor, with poor response to gefitinib: A case report". Oncology Letters 8, no. 3 (2014): 1039-1042. https://doi.org/10.3892/ol.2014.2321
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