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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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October 2014 Volume 8 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Levofloxacin for the treatment of severe refractory BK virus‑associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases

  • Authors:
    • Tayfur Toptas
    • Isik Kaygusuz‑Atagunduz
    • Haluk Tarik Kani
    • Cafer Adiguzel
    • Tulin Firatli‑Tuglular

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Van Training and Research Hospital, Van 65100, Turkey, Department of Hematology, Marmara University Hospital, Istanbul 34890, Turkey
  • Pages: 1775-1777
    |
    Published online on: July 25, 2014
       https://doi.org/10.3892/ol.2014.2381
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Abstract

BK‑virus (BKV) is an important etiological agent for late‑onset hemorrhagic cystitis (HC) in patients undergoing hematopoietic stem cell transplantation. Late‑onset HC causes significant morbidity among these patients. Therapeutic approaches remain predominantly symptomatic. Several treatment options have been used with variable success rates. Cidofovir has the highest specificity against BKV; however, its lack of availability in the majority of countries, high costs and potential nephrotoxic effects limit its use. The present study reports three cases of severe and prolonged BKV‑associated HC (BKHC). HC was resolved in all three of the patients using oral levofloxacin. Thus, levofloxacin may be an effective treatment modality for achieving complete clinical and molecular response in patients with refractory, severe BKHC.
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1 

Gratwohl A, Brand R, Frassoni F, et al: Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: an EBMT analysis of lethal infectious complications and changes over calendar time. Bone Marrow Transplant. 36:757–769. 2005.

2 

Harkensee C, Vasdev N, Gennery AR, Willetts IE and Taylor C: Prevention and management of BK-virus associated haemorrhagic cystitis in children following haematopoietic stem cell transplantation - a systematic review and evidence-based guidance for clinical management. Br J Haematol. 142:717–731. 2008.

3 

Gardner SD, Field AM, Coleman DV, et al: New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1:1253–1257. 1971.

4 

Leung AY, Suen CK, Lie AK, Liang RH, Yuen KY and Kwong YL: Quantification of polyoma BK viruria in hemorrhagic cystitis complicating bone marrow transplantation. Blood. 98:1971–1978. 2001.

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Leung AY, Mak R, Lie AK, et al: Clinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantation. Bone Marrow Transplant. 29:509–513. 2002.

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Focosi D and Kast RE: Hyaluronate and risperidone for hemorrhagic cystitis. Bone Marrow Transplant. 39:572007.

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Leung AY, Chan MT, Yuen KY, et al: Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 40:528–537. 2005.

8 

Kwon HJ, Kang JH, Lee JW, Chung NG, Kim HK and Cho B: Treatment of BK virus-associated hemorrhagic cystitis in pediatric hematopoietic stem cell transplant recipients with cidofovir: a single-center experience. Transpl Infect Dis. 15:569–574. 2013.

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Gabardi S, Waikar SS, Martin S, et al: Evaluation of fluoroquinolones for the prevention of BK viremia after renal transplantation. Clin J Am Soc Nephrol. 5:1298–1304. 2010.

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Lee BT, Gabardi S, Grafals M, et al: Efficacy of levofloxacin in the treatment of BK viremia: a multicenter, double-blinded, randomized, placebo-controlled trial. Clin J Am Soc Nephrol. 9:583–589. 2014.

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Copy and paste a formatted citation
Spandidos Publications style
Toptas T, Kaygusuz‑Atagunduz I, Kani HT, Adiguzel C and Firatli‑Tuglular T: Levofloxacin for the treatment of severe refractory BK virus‑associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases. Oncol Lett 8: 1775-1777, 2014.
APA
Toptas, T., Kaygusuz‑Atagunduz, I., Kani, H.T., Adiguzel, C., & Firatli‑Tuglular, T. (2014). Levofloxacin for the treatment of severe refractory BK virus‑associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases. Oncology Letters, 8, 1775-1777. https://doi.org/10.3892/ol.2014.2381
MLA
Toptas, T., Kaygusuz‑Atagunduz, I., Kani, H. T., Adiguzel, C., Firatli‑Tuglular, T."Levofloxacin for the treatment of severe refractory BK virus‑associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases". Oncology Letters 8.4 (2014): 1775-1777.
Chicago
Toptas, T., Kaygusuz‑Atagunduz, I., Kani, H. T., Adiguzel, C., Firatli‑Tuglular, T."Levofloxacin for the treatment of severe refractory BK virus‑associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases". Oncology Letters 8, no. 4 (2014): 1775-1777. https://doi.org/10.3892/ol.2014.2381
Copy and paste a formatted citation
x
Spandidos Publications style
Toptas T, Kaygusuz‑Atagunduz I, Kani HT, Adiguzel C and Firatli‑Tuglular T: Levofloxacin for the treatment of severe refractory BK virus‑associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases. Oncol Lett 8: 1775-1777, 2014.
APA
Toptas, T., Kaygusuz‑Atagunduz, I., Kani, H.T., Adiguzel, C., & Firatli‑Tuglular, T. (2014). Levofloxacin for the treatment of severe refractory BK virus‑associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases. Oncology Letters, 8, 1775-1777. https://doi.org/10.3892/ol.2014.2381
MLA
Toptas, T., Kaygusuz‑Atagunduz, I., Kani, H. T., Adiguzel, C., Firatli‑Tuglular, T."Levofloxacin for the treatment of severe refractory BK virus‑associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases". Oncology Letters 8.4 (2014): 1775-1777.
Chicago
Toptas, T., Kaygusuz‑Atagunduz, I., Kani, H. T., Adiguzel, C., Firatli‑Tuglular, T."Levofloxacin for the treatment of severe refractory BK virus‑associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases". Oncology Letters 8, no. 4 (2014): 1775-1777. https://doi.org/10.3892/ol.2014.2381
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