Expression characteristics of FHIT, p53, BRCA2 and MLH1 in families with a history of oesophageal cancer in a region with a high incidence of oesophageal cancer

  • Authors:
    • Zhiwei Chang
    • Weijie Zhang
    • Zhijun Chang
    • Min Song
    • Yanru Qin
    • Fubao Chang
    • Haiyun Guo
    • Qingli Wei
  • View Affiliations

  • Published online on: November 7, 2014     https://doi.org/10.3892/ol.2014.2682
  • Pages: 430-436
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Abstract

The aim of the present study was to determine the changes to the expression levels of fragile histidine triad (FHIT), breast cancer type 2 susceptibility protein (BRCA2), MutL homolog 1 (MLH1) and tumour protein 53 (p53) exhibited by families with a history of oesophageal cancer in a region that has a high incidence of oesophageal cancer, and to determine the association of these changes with the cancer history of the families. Immunohistochemistry was used to detect the protein expression of FHIT, p53, BRCA2, and MLH1 in the excised specimens of cancer tissues from 74 oesophageal cancer patients (positive family history of oesophageal cancer [OCFH +], n=33; negative family history of oesophageal cancer [OCFH -], n=41) from a region with a high incidence of oesophageal cancer. The positive expression rates of FHIT (61%; 45/74), BRCA2 (50%; 37/74) and MLH1 (27%; 9/33) in the oesophageal cancer tissues were significantly lower than those in the healthy tissues adjacent to the cancer (97% [29/30], 87% [26/30] and 73% [25/41], respectively). A significant difference was identified between the positive expression rates (P<0.01). However, FHIT, p53, BRCA2 and MLH1 expression demonstrated no significant affect on clinicopathological changes, such as oesophageal cancerous tissue differentiation, the degree of infiltration and cancer cell metastasis. The FHIT, BRCA2 and MLH1 expression levels were identified to be significantly lower in the cancer tissues from OCFH + patients. This result indicates that the expression levels of FHIT, BRCA2, and MLH1 are important molecular indices of genetic susceptibility to oesophageal cancer.
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January-2015
Volume 9 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chang Z, Zhang W, Chang Z, Song M, Qin Y, Chang F, Guo H and Wei Q: Expression characteristics of FHIT, p53, BRCA2 and MLH1 in families with a history of oesophageal cancer in a region with a high incidence of oesophageal cancer. Oncol Lett 9: 430-436, 2015.
APA
Chang, Z., Zhang, W., Chang, Z., Song, M., Qin, Y., Chang, F. ... Wei, Q. (2015). Expression characteristics of FHIT, p53, BRCA2 and MLH1 in families with a history of oesophageal cancer in a region with a high incidence of oesophageal cancer. Oncology Letters, 9, 430-436. https://doi.org/10.3892/ol.2014.2682
MLA
Chang, Z., Zhang, W., Chang, Z., Song, M., Qin, Y., Chang, F., Guo, H., Wei, Q."Expression characteristics of FHIT, p53, BRCA2 and MLH1 in families with a history of oesophageal cancer in a region with a high incidence of oesophageal cancer". Oncology Letters 9.1 (2015): 430-436.
Chicago
Chang, Z., Zhang, W., Chang, Z., Song, M., Qin, Y., Chang, F., Guo, H., Wei, Q."Expression characteristics of FHIT, p53, BRCA2 and MLH1 in families with a history of oesophageal cancer in a region with a high incidence of oesophageal cancer". Oncology Letters 9, no. 1 (2015): 430-436. https://doi.org/10.3892/ol.2014.2682