Diagnostic and prognostic serum marker of cholangiocarcinoma (Review)
- Authors:
- Xiaojun Zeng
- Hualin Tao
-
Affiliations: Department of Laboratory Medicine, Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China, Department of Laboratory Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China - Published online on: November 10, 2014 https://doi.org/10.3892/ol.2014.2696
- Pages: 3-8
This article is mentioned in:
Abstract
Khan SA, Davidson BR, Goldin RD, et al: Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update. Gut. 61:1657–1669. 2012. View Article : Google Scholar : PubMed/NCBI | |
Gentilini A, Rombouts K, Galastri S, et al: Role of the stromal-derived factor-1 (SDF-1)-CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma. J Hepatol. 57:813–820. 2012. View Article : Google Scholar : PubMed/NCBI | |
Limpaiboon T: Epigenetic aberrations in cholangiocarcinoma: potential biomarkers and promising target for novel therapeutic strategies. Asian Pac J Cancer Prev. 13:41–45. 2012.PubMed/NCBI | |
Boonjaraspinyo S, Wu Z, Boonmars T, Kaewkes S, et al: Overexpression of PDGFA and its receptor during carcinogenesis of Opisthorchis viverrini-associated cholangiocarcinoma. Parasitol Int. 61:145–150. 2012. View Article : Google Scholar | |
Buranrat B, Chau-in S, Prawan A, et al: NQO1 Expression Correlates with Cholangiocarcinoma Prognosis. Asian Pac J Cancer Prev. 13:131–136. 2012.PubMed/NCBI | |
Taylor-Robinson SD, Toledano MB, Arora S, et al: Increase in mortalityrates for intrahepatic cholangiocarcinoma in England and Wales 1968–1998. Gut. 48:816–820. 2001. View Article : Google Scholar : PubMed/NCBI | |
Tanaka M, Tanaka H, Tsukuma H, et al: Risk factors for intrahepatic cholangiocarcinoma: a possible role of hepatitis B virus. Journal of Viral Hepatitis. 17:742–748. 2010. View Article : Google Scholar | |
Li M, Li J, Li P, et al: Hepatitis B virus infection increases the risk of cholangiocarcinoma: a meta-analysis and systematic review. J Gastroenterol Hepatol. 27:1561–1568. 2012. View Article : Google Scholar : PubMed/NCBI | |
Sempoux C, Jibara G, Ward SC, et al: Intrahepatic cholangiocarcinoma: new insights in pathology. Semin Liver Dis. 31:49–60. 2011. View Article : Google Scholar : PubMed/NCBI | |
Suarez-Munoz MA, Fernandez-Aguilar JL, Sanchez-Perez B, et al: Risk factors and classifications of hilar cholangiocarcinoma. World J Gastrointest Oncol. 15:132–138. 2013. View Article : Google Scholar | |
Zhou Y, Zhou Q, Lin Q, et al: Evaluation of risk factors for extrahepatic cholangiocarcinoma: ABO blood group, hepatitis B virus and their synergism. Int J Cancer. 15:1867–1875. 2013. View Article : Google Scholar | |
Sawanyawisuth K: Genes and cholangiocarcinoma. Southeast Asian J Trop Med Public Health. 40:701–712. 2009.PubMed/NCBI | |
Fava G: Molecular mechanisms of cholangiocarcinoma. World J Gastrointest Pathophysiol. 15:12–22. 2010. | |
Briggs CD, Neal CP, Mann CD, et al: Prognostic molecular markers in cholangiocarcinoma: A systematic review. Eur J Cancer. 45:33–47. 2009. View Article : Google Scholar | |
Borger DR, Tanabe KK, Fan KC, et al: Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist. 17:72–79. 2012. View Article : Google Scholar : | |
Subimerb C, Pinlaor S, Lulitanond V, et al: Circulating CD14+CD16+ monocyte levels predict tissue invasive character of cholangiocarcinoma. Clin Exp Immunol. 161:471–479. 2010. View Article : Google Scholar : PubMed/NCBI | |
Gu FM, Gao Q, Shi GM, et al: Intratumoral IL-17+ cells and neutrophils show strong prognostic significance in intrahepatic cholangiocarcinoma. Ann Surg Oncol. 19:2506–2514. 2012. View Article : Google Scholar : PubMed/NCBI | |
Utispan K, Thuwajit P, Abiko Y, et al: Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker. Mol Cancer. 9:1–20. 2010. View Article : Google Scholar | |
Keeratichamroen S, Leelawat K, Thongtawee T, et al: Expression of CD24 in cholangiocarcinoma cells is associated with disease progression and reduced patient survival. Int J Oncol. 39:873–881. 2011.PubMed/NCBI | |
Yonglitthipagon P, Pairojkul C, Chamgramol Y, et al: Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker. Int J Parasitol. 40:1203–1212. 2010. View Article : Google Scholar : PubMed/NCBI | |
Khan SA, Davidson BR, Goldin R, et al: Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus document. Gut. 51:1–9. 2002. View Article : Google Scholar | |
Li YG and Zhang N: Clinical significance of serum tumour M2-PK and CA19-9 detection in the diagnosis of cholangiocarcinoma. Dig Liver Dis. 41:605–608. 2009. View Article : Google Scholar : PubMed/NCBI | |
Leelawat K, Narong S, Wannaprasert J, et al: Prospective study of MMP7 serum levels in the diagnosis of cholangiocarcinoma. World J Gastroenterol. 16:4697–4703. 2010. View Article : Google Scholar : PubMed/NCBI | |
Singh S, Tang SJ, Sreenarasimhaiah J, et al: The clinical utility and limitations of serum carbohydrate antigen (CA19-9) as a diagnostic tool for pancreatic cancer and cholangiocarcinoma. Dig Dis Sci. 56:2491–2496. 2011. View Article : Google Scholar : PubMed/NCBI | |
Jo JH, Chung MJ, Park JY, et al: High serum CA19-9 levels are associated with an increased risk of cholangiocarcinoma in patients with intrahepatic duct stones: a case-control study. Surg Endosc. 27:4210–4216. 2013. View Article : Google Scholar : PubMed/NCBI | |
Wannhoff A, Hov JR, Folseraas T, et al: FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis. 59:1278–1284. 2013.PubMed/NCBI | |
Sinakos E, Saenger AK, Keach J, et al: Many patients with primary sclerosing cholangitis and increased serum levels of carbohydrate antigen 19-9 do not have cholangiocarcinoma. Clin Gastroenterol Hepatol. 9:434–439. 2011. View Article : Google Scholar : PubMed/NCBI | |
Liu SL, Song ZF, Hu QG, et al: Serum carbohydrate antigen (CA) 19-9 as a prognostic factor in cholangiocarcinoma: a meta-analysis. Front Med China. 4:457–462. 2010. View Article : Google Scholar : PubMed/NCBI | |
Juntermanns B, Radunz S, Heuer M, et al: Tumor markers as a diagnostic key for hilar cholangiocarcinoma. Eur J Med Res. 15:357–361. 2010. View Article : Google Scholar : PubMed/NCBI | |
Silsirivanit A, Araki N, Wongkham C, et al: A novel serum carbohydrate marker on mucin 5AC: values for diagnostic and prognostic indicators for cholangiocarcinoma. Cancer. 117:3393–3403. 2011. View Article : Google Scholar : PubMed/NCBI | |
Sawanyawisuth K, Silsirivanit A, Kunlabut K, et al: A novel carbohydrate antigen expression during development of Opisthorchis viverrini-associated cholangiocarcinoma in golden hamster: a potential marker for early diagnosis. Parasitol Int. 61:151–154. 2012. View Article : Google Scholar | |
Silsirivanit A, Araki N, Wongkham C, et al: CA-S27: A novel Lewis a associated carbohydrate epitope is diagnostic and prognostic for cholangiocarcinoma. Cancer Sci. 104:1278–1284. 2013. View Article : Google Scholar : PubMed/NCBI | |
Tao LY, Cai L, He XD, et al: Comparison of serum tumor markers for intrahepatic cholangiocarcinoma and hepatocellular carcinoma. Am Surg. 76:1210–1213. 2010.PubMed/NCBI | |
Leelawat K, Sakchinabut S, Narong S, et al: Detection of serum MMP-7 and MMP-9 in cholangiocarcinoma patients: evaluation of diagnostic accuracy. BMC Gastroenterol. 9:1–8. 2009. View Article : Google Scholar | |
Prakobwong S, Charoensuk L, Hiraku Y, et al: Plasma hydroxyproline, MMP-7 and collagen I as novel predictive risk markers of hepatobiliary disease-associated cholangiocarcinoma. Int J Cancer. 131:E416–E424. 2012. View Article : Google Scholar | |
Brewer HB Jr, Fairwell T, LaRue A, et al: The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins. Biochem Biophys Res Commun. 80:623–630. 1978. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Dai S, Zhang Z, et al: Characterization of apolipoprotein A-I as a potential biomarker for cholangiocarcinoma. Eur J Cancer Care (Engl). 18:625–635. 2009. View Article : Google Scholar | |
Leelawat K, Narong S, Wannaprasert J, et al: Serum NGAL to clinically distinguish cholangiocarcinoma from benign biliary tract diseases. Int J Hepatol. 2011:1–6. 2011. View Article : Google Scholar | |
Flower DR: The lipocalin protein family: structure and function. Biochem J. 318:1–14. 1996.PubMed/NCBI | |
Srisomsap C, Sawangareetrakul P, Subhasitanont P, et al: Proteomic Studies of Cholangiocarcinoma and Hepatocellular Carcinoma Cell Secretomes. J Biomed Biotechnol. 2010:1–18. 2010. View Article : Google Scholar | |
Jie Z, Cai Y, Yang W, et al: Protective effects of α1-antitrypsin on acute lung injury inrabbits induced by endotoxin. Chin Med J (Engl). 116:1678–1682. 2003. | |
Jamnongkan W, Techasen A, Thanan R, et al: Oxidized alpha-1 antitrypsin as a predictive risk marker of opisthorchiasis-associated cholangiocarcinoma. Tumour Biol. 34:695–704. 2013. View Article : Google Scholar | |
Sriwanitchrak P, Viyanant V, Chaijaroenkul W, et al: Proteomics analysis and evaluation of biomarkers for detection of cholangiocarcinoma. Asian Pac J Cancer Prev. 12:1503–1510. 2011.PubMed/NCBI | |
Tang W, Inagaki Y, Kokudo N, et al: KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression. World J Gastroenterol. 11:5450–5454. 2005.PubMed/NCBI | |
Xu H, Inagaki Y, Tang W, et al: Elevation of serum KL-6 mucin levels in patients with cholangiocarcinoma. Hepatogastroenterology. 55:2000–2004. 2008. | |
Khoontawad J, Hongsrichan N, Chamgramol Y, et al: Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. Tumour Biol. 35:1029–1039. 2013. View Article : Google Scholar : PubMed/NCBI | |
Tian M, Cui YZ, Song GH, et al: Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer. 8:1–11. 2008. View Article : Google Scholar | |
Jackson D, Craven RA, Hutson RC, et al: Proteomic profiling identifies afamin as a potential biomarker for ovarian cancer. Clin Cancer Res. 13:7370–7379. 2007. View Article : Google Scholar : PubMed/NCBI | |
Dieplinger H, Ankerst DP, Burges A, et al: Afamin and Apolipoprotein A-IV: Novel protein markers for ovarian cancer. Cancer Epidemiol Biomarkers Prev. 18:1127–1133. 2009. View Article : Google Scholar : PubMed/NCBI | |
Dieplinger B, Egger M, Gabriel C, et al: Analytical characterization and clinical evaluation of an enzyme-linked immunosorbent assay for measurement of afamin in human plasma. Clin Chim Acta. 425:236–241. 2013. View Article : Google Scholar : PubMed/NCBI | |
Tolek A, Wongkham C, Proungvitaya S, et al: Serum α1β-glycoprotein and afamin ratio as potential diagnostic and prognostic markers in cholangiocarcinoma. Exp Biol Med (Maywood). 237:1142–1149. 2012. View Article : Google Scholar | |
Zhang X, Xiao Z, Liu X, et al: The potential role of ORM2 in the development of colorectal cancer. PLoS One. 7:1–7. 2012. | |
Nagahara M, Nishida N, Iwatsuki M, et al: Kinesin 18A expression: clinical relevance to colorectal cancer progression. Int J Cancer. 129:2543–2552. 2011. View Article : Google Scholar : PubMed/NCBI | |
Rucksaken R, Khoontawad J, Roytrakul S, et al: Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma. Cancer Biomark. 12:81–95. 2012. | |
Wang Y, Zhou B, Li J, et al: Inhibitors of 5-lipoxygenase inhibit expression of intercellular adhesion molecule-1 in human melanoma cells. Acta Pharmacol Sin. 25:672–677. 2004.PubMed/NCBI | |
Touvier M, Fezeu L, Ahluwalia N, et al: Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk. World J Gastroenterol. 18:2805–2812. 2012. View Article : Google Scholar : PubMed/NCBI | |
Song WB, Lv YH, Zhang ZS, et al: Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease. World J Gastroenterol. 15:3916–3919. 2009. View Article : Google Scholar : PubMed/NCBI | |
Janan M, Proungvitaya S, Limpaiboon T, et al: Serum adhesion molecule-1 (icam-1) as a potential prognostic marker for cholangiocarcinoma patients. Asian Pac J Cancer Prev. 13:107–114. 2012.PubMed/NCBI | |
Schneider J, Bitterlich N and Schulze G: Improved sensitivity in the diagnosis of gastro-intestinal tumors by Fuzzy Logic-based tumor marker profiles including the tumor M2-PK. Anticancer Res. 25:1507–1515. 2005.PubMed/NCBI | |
Yin L, Wang X, Luo C, et al: The value of expression of M2-PK and VEGF in patients with advanced gastric cancer. Cell Biochem Biophys. 67:1033–1039. 2013. View Article : Google Scholar : PubMed/NCBI | |
Koss K, Harrison RF, Gregory J, et al: The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett’s oesophagus. J Clin Pathol. 57:1156–1159. 2004. View Article : Google Scholar : PubMed/NCBI | |
Wu G, Bazer FW, Burghardt RC, et al: Proline and hydroxyproline metabolism: implications for animal and human nutrition. Amino Acids. 40:1053–1063. 2011. View Article : Google Scholar | |
Jagtap VR and Ganu JV: Effect of antiresorptive therapy on urinary hydroxyproline in postmenopausal osteoporosis. Indian J Clin Biochem. 27:90–93. 2012. View Article : Google Scholar : | |
Kristiansen TZ, Harsha HC, Grønborg M, et al: Differential membrane proteomics using 18O-labeling to identify biomarkers for cholangiocarcinoma. J Proteome Res. 7:4670–4677. 2008. View Article : Google Scholar : PubMed/NCBI | |
Li W, Wang X, Li B, et al: Diagnostic significance of overexpression of Golgi membrane protein 1 in prostate cancer. Urology. 80:e1–e7. 2012. View Article : Google Scholar | |
Chen MH, Jan YH, Chang PM, et al: Expression of GOLM1 correlates with prognosis in human hepatocellular carcinoma. Ann Surg Oncol. 20:616–624. 2013. View Article : Google Scholar | |
Beyazit Y, Purnak T, Suvak B, et al: Increased ACE in extrahepatic cholangiocarcinoma as a clue for activated RAS in biliary neoplasms. Clin Res Hepatol Gastroenterol. 35:644–649. 2011. View Article : Google Scholar : PubMed/NCBI | |
Liu JB, Yu ZP, Zhao WZ, et al: Liquid chromatographic assay of peptides activity with inhibiting angiotensin converting enzyme. Chem Res Chin Univ. 26:712–716. 2010. | |
Kósa JP, Horváth P, Wölfling J, et al: CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells. World J Gastroenterol. 19:2621–2628. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kennedy L, Baker K, Hodges K, et al: Dysregulation of vitamin D3 synthesis leads to enhanced cholangiocarcinoma growth. Dig Liver Dis. 45:316–322. 2013. View Article : Google Scholar : PubMed/NCBI | |
Hunsawong T, Singsuksawat E, In-chon N, et al: Estrogen is increased in male cholangiocarcinoma patients’ serum and stimulates invasion in cholangiocarcinoma cell lines in vitro. J Cancer Res Clin Oncol. 138:1311–1320. 2012. View Article : Google Scholar : PubMed/NCBI | |
Yin X, Zheng SS, Zhang BH, et al: Elevation of serum c-glutamyltransferase as a predictorn of aggressive tumor behaviors and unfavorable prognosis in patients with intrahepatic cholangiocarcinoma: analysis of a large monocenter study. Eur J Gastroenterol Hepatol. 25:1408–1414. 2013. View Article : Google Scholar : PubMed/NCBI | |
Forrest LM, McMillan DC, McArdle CS, et al: Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer. Br J Cancer. 89:1028–1030. 2003. View Article : Google Scholar : PubMed/NCBI | |
Oshiro Y, Sasaki R, Fukunaga K, et al: Inflammation-based prognostic score is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Sci. 20:389–395. 2013. View Article : Google Scholar | |
Specht S, Isse K, Nozaki I, et al: SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis. Clin Exp Metastasis. 30:877–890. 2013. View Article : Google Scholar : PubMed/NCBI | |
Sato Y, Harada K, Sasaki M, et al: Heat shock proteins 27 and 70 are potential biliary markers for the detection of cholangiocarcinoma. Am J Pathol. 180:123–130. 2012. View Article : Google Scholar |