Oncocytic carcinoma of the salivary gland with thymoma: A case report and review of the literature

Cao,Yongcheng; Zhu,Ming; Mao,Ruiqi; Cao,Ruixue; Yu,Guoli; Niu,Aijun

doi:10.3892/ol.2014.2707

Oncocytic carcinoma of the salivary gland with thymoma: A case report and review of the literature

Authors:
- Yongcheng Cao
- Ming Zhu
- Ruiqi Mao
- Ruixue Cao
- Guoli Yu
- Aijun Niu
View Affiliations

Affiliations: Department of Pathology, General Hospital of Jinan Military Command, Jinan, Shandong 250031, P.R. China, Department of Radiology, General Hospital of Jinan Military Command, Jinan, Shandong 250031, P.R. China, Department of Laboratory Medicine, General Hospital of Jinan Military Command, Jinan, Shandong 250031, P.R. China
Published online on: November 19, 2014 https://doi.org/10.3892/ol.2014.2707
Pages: 681-684

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Oncocytic carcinoma (OC) arising in the salivary gland is a very rare tumor with only 32 previously reported cases. In this report, we describe a novel case of oncocytic carcinoma with associated thymoma, which arose in the left parotid gland of a 66‑year‑old male with a history of a painless left parotid mass for 1 year. Oncocytes are large, polygonal cells that are characterized by marked cellular atypia, frequent mitoses, wide eosinophilic granular cytoplasm, a central nucleus and a prominent nucleolus. The follow‑up data showed no evidence of recurrence and the patient is in a good health 20 months after the surgery. In the current case, the patient had not only OC but also thymoma, which is exceedingly rare and may represent the first documented case in the literature.

View Figures

View References

1	Ellis GL, Auclair PL, Gnepp DR and Goode PK: Other malignant epithelial neoplasms. Surgical Pathology of the Salivary Glands. Ellis GL, Auclair PL and Gnepp DR: Philadelphia: W. Saunders; pp. 455–488. 1991
2	Ellis GL and Auclair PL: Tumors of the salivary glands. Atlas of Tumor Pathology: Third Series, Fascicle 17. Armed Forces Institute of Pathology; Washington, DC: pp. 318–324. 1996
3	Bauer WH and Bauer JD: Classification of glandular tumors of salivary glands; study of one-hundred forty-three cases. AMA Arch Pathol. 55:328–346. 1953.PubMed/NCBI
4	Guclu E, Oghan F, Ozturk O, Alper M and Egeli E: A rare malignancy of the parotid gland: oncocytic carcinoma. Eur Arch Otorhinolaryngol. 262:567–569. 2005. View Article : Google Scholar
5	Mizutari K, Naganishi H and Tanaka Y: Oncocytic carcinoma in the submandibular gland: report of a case based on anti-mitochondrial immunohistochemical observations. Auris Nasus Larynx. 32:305–308. 2005. View Article : Google Scholar : PubMed/NCBI
6	Kimura M, Furuta T, Hashimoto S, Takano T and Nagao K: Oncocytic carcinoma of the parotid gland. A case report. Acta Cytol. 47:1099–1102. 2003. View Article : Google Scholar : PubMed/NCBI
7	Wischerath H, Brehmer D, Hesse G and Laubert A: Oncocytic adenocarcinoma of the submandibular gland. HNO. 50:565–569. 2002.(In German). View Article : Google Scholar : PubMed/NCBI
8	Lombardi D, Piccioni M, Farina D, Morassi ML and Nicolai P: Oncocytic carcinoma of the maxillary sinus: a rare neoplasm. Eur Arch Otorhinolaryngol. 263:528–531. 2006. View Article : Google Scholar : PubMed/NCBI
9	Sugiyama T, Nakagawa T, Narita M, Nakamura S, Inui M and Tagawa T: Pedunculated oncocytic carcinoma in buccal mucosa: immunohistochemical and ultrastructural studies. Oral Dis. 12:324–328. 2006. View Article : Google Scholar : PubMed/NCBI
10	Ardekian L, Manor R, Peled M and Laufer D: Malignant oncocytoma of the parotid gland: case report and analysis of the literature. Oral Maxillofac Surg. 57:325–328. 1999. View Article : Google Scholar
11	Cinar U, Vural C, Basak T and Turgut S: Oncocytic carcinoma of the parotid gland: report of a new case. Ear Nose Throat J. 82:699–701. 2003.PubMed/NCBI
12	Muramatsu T, Hashimoto S, Lee MW, Chung CK, Matsuzaki K, Inoue T, Noma H and Shimono M: Oncocytic carcinoma arising in submandibular gland with immunohistochemical observations and review of the literature. Oral Oncol. 39:199–203. 2003. View Article : Google Scholar : PubMed/NCBI
13	Ozawa H, Fujii M, Matsunaga T, Masuda K, Hirose S and Taiji H: Oncocytic carcinoma of the parotid gland. J Otolaryngol. 35:189–192. 2006.PubMed/NCBI
14	Nakada M, Nishizaki K, Akagi H, Masuda Y and Yoshino T: Oncocytic carcinoma of the submandibular gland: a case report and literature review. J Oral Pathol Med. 27:225–228. 1998. View Article : Google Scholar : PubMed/NCBI
15	Corbridge RJ, Gallimore AP, Dalton CG and O’Flynn PE: Oncocytomas of the upper jaw. Head Neck. 18:374–380. 1996. View Article : Google Scholar : PubMed/NCBI
16	Yang GZ, Gao LX and Ding HY: Salivary gland carcinoma with eosinophilia neuroendocrine differentiation. Chin J Pathol. 33:582–583. 2004.
17	Wang SY, Lou JL and DU XH: Oncocytic Carcinoma of Parotid Gland: A Case Report. J Oncol. 14:689–691. 2008.
18	Tian XQ and Wang WZ: Oncocytic carcinoma of Salivary gland, a case report. Zhong liu yan jiu yu lin chuang. 14:252–253. 2002.
19	Dong DX, Shi PX and Li YL: Salivary Gland Cancer: A case report. J Diagn Pathol. 8:183–184. 2001.
20	Zhou CX, Shi DY, Ma DQ, Zhang JG, Yu GY and Gao Y: Primary oncocytic carcinoma of the salivary glands: A clinicopathologic and immunohistochemical study of 12 cases. Oral Oncol. 46:773–778. 2010. View Article : Google Scholar : PubMed/NCBI
21	Lee WY and Chang SL: Fine needle aspiration cytology of oncocytic carcinoma of the submandibular gland with pre-existing oncocytoma: a case report. J Cytopathology. 21:339–341. 2010. View Article : Google Scholar
22	Gallego L, García-Consuegra L, Fuente E, Calvo N and Junquera L: Oncocytic carcinoma of the parotid gland with late cervical lymph node metastases: a case report. J Med Case Rep. 5:112011. View Article : Google Scholar : PubMed/NCBI
23	Fornasiero A, Daniele O, Ghiotto C, et al: Chemotherapy of invasive thymoma. J Clin Oncol. 8:1419–1423. 1990.PubMed/NCBI
24	Detterbeck FC and Parsons AM: Thymic tumors. Ann Thorac Surg. 77:1860–1869. 2004. View Article : Google Scholar : PubMed/NCBI
25	Marx A, Harris NL, Strobel Ph, et al: Thymomas. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Travis DW, Brambilla E, Muller-Hermelink HK and Harris CC: IARC Press; Lyon: pp. 152–157. 2004
26	Hamperl H: Beitrage zur normalen und pathologischen histology menschlicher speicheldrusen. Z Microanat Forsch. 27:1–55. 1931.(In German).
27	Alberty J, August C and Stoll W: Oncocytic neoplasms of the parotid gland. Differential diagnosis, clinical course and review of the literature. HNO. 49:109–117. 2001.(In German). View Article : Google Scholar : PubMed/NCBI
28	Dardick I, Birek C, Lingen MW and Rowe PE: Differentiation and the cytomorphology of salivary gland tumors with specific reference to oncocytic metaplasia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 88:691–701. 1999. View Article : Google Scholar
29	Linnane AW1, Marzuki S, Ozawa T and Tanaka M: Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet. 25:642–645. 1989. View Article : Google Scholar
30	Sciubba JJ and Shimono M: Oncocytic carcinoma. World Health Organization Classification of Tumors: Pathology and Genetics: Head and Neck Tumours. Barnes L, Eveson JW, Reichart D and Sidransky D: IARC Press; Lyon: pp. 2352005
31	Sugimoto T, Wakizono S, Uemura T, Tsuneyoshi M and Enjoji M: Malignant oncocytoma of the parotid gland: a case report with an immunohistochemical and ultrastructural study. J Laryngol Otol. 107:69–74. 1993. View Article : Google Scholar : PubMed/NCBI
32	Gray SR, Cornog JL Jr and Seo IS: Oncocytic neoplasms of salivary glands: a report of fifteen cases including two malignant oncocytomas. Cancer. 38:1306–1317. 1976. View Article : Google Scholar : PubMed/NCBI
33	Ito K, Tsukuda M, Kawabe R, et al: Benign and malignant oncocytoma of the salivary glands with an immunohistochemical evaluation of Ki-67. ORL J Otorhinolaryngol Relat Spec. 62:338–341. 2000. View Article : Google Scholar : PubMed/NCBI
34	Zhou CX and Gao Y: Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. Oral Oncol. 45:e232–e238. 2009. View Article : Google Scholar : PubMed/NCBI
35	Yang T and Guo LN: Oncocytic carcinoma. Diagnostic Pathology: First Series. Liu TH: People’s Medical Publishing Press; Beijing: pp. 617–618. 2013
36	Brandwein MS and Huvos AG: Oncocytic tumors of major salivary glands: a study of 68 cases with follow-up of 44 patients. Am J Surg Pathol. 15:514–528. 1991. View Article : Google Scholar : PubMed/NCBI
37	Shintaku M and Honda T: Identification of oncocytic lesions of salivary glands by anti-mitochondrial immunohistochemistry. Histopathology. 31:408–411. 1997. View Article : Google Scholar
38	Goode RK and Corio RL: Oncocytic adenocarcinoma of salivary glands. Oral Surg Oral Med Oral Pathol. 65:61–66. 1988. View Article : Google Scholar : PubMed/NCBI