Expression and significance of glucose transporter-1, P-glycoprotein, multidrug resistance-associated protein and glutathione S-transferase-π in laryngeal carcinoma
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- Published online on: December 1, 2014 https://doi.org/10.3892/ol.2014.2752
- Pages: 806-810
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Abstract
Increasing glucose transporter‑1 (GLUT‑1) activity is one of the most important ways to increase the cellular influx of glucose. We previously demonstrated that increased GLUT‑1 expression was an independent predictor of survival in patients with laryngeal carcinoma. Thus, GLUT‑1 may present a novel therapeutic target in laryngeal carcinoma. In this study, the expression of GLUT‑1, P‑glycoprotein (P‑gp), multidrug resistance‑associated protein 1 (MRP1) and glutathione S‑transferase‑π (GST‑π) in laryngeal carcinomas was investigated by immunohistochemistry. Additionally, possible correlations between GLUT‑1 and P‑gp, MRP1 and GST‑π and various clinicopathological parameters were analyzed. In this study, 52.9% (18/34), 58.8% (20/34), 20.6% (7/34) and 58.8% (20/34) of the laryngeal carcinomas were positive for GLUT‑1, P‑gp, MRP1 and GST‑π, respectively. The expression of GLUT‑1, P‑gp, MRP1 and GST‑π was higher in laryngeal carcinoma specimens when compared with laryngeal precancerous lesions (P<0.05). Pearson's correlation analysis showed correlations between GLUT‑1 and P‑gp (r=0.364; P=0.034), GLUT‑1 and MRP1 (r=0.359; P=0.037) and P‑gp and GST‑π (r=0.426; P=0.012). GLUT‑1 expression was found to significantly correlate with tumor‑node‑metastasis classification (P=0.02) and clinical stage (P=0.037). Furthermore, P‑gp was found to significantly correlate with clinical stage (P=0.026). Univariate analysis showed that MRP1 expression was significantly associated with poor survival (c2=5.16; P=0.023). Multivariate analysis revealed that lymph node metastasis (P=0.009) and MRP1 overexpression (P=0.023) were significant predictors of poor survival. In the present study, the expression of GLUT‑1, P‑gp, MRP1 and GST‑π in laryngeal carcinomas was investigated, as well as the correlations between these proteins. P‑gp was found to significantly correlate with clinical stage, while MRP1 overexpression was significantly associated with poor survival.
