Adult hepatic cavernous hemangioma with highly elevated α-fetoprotein: A case report and review of the literature

Wang,Huan‑Yu; Zhang,Liang; Wu,Jian; Zhang,Zi‑Jian; Peng,Bao‑Gang; Liang,Li‑Jian; Zhou,Qi

doi:10.3892/ol.2014.2769

Adult hepatic cavernous hemangioma with highly elevated α-fetoprotein: A case report and review of the literature

Authors:
- Huan‑Yu Wang
- Liang Zhang
- Jian Wu
- Zi‑Jian Zhang
- Bao‑Gang Peng
- Li‑Jian Liang
- Qi Zhou
View Affiliations

Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China, Diagnostic Imaging and Interventional Radiology Department, Cancer Center, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China
Published online on: December 4, 2014 https://doi.org/10.3892/ol.2014.2769
Pages: 637-640

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

A 47‑year‑old male presented with a six‑month history of fatigue and a four‑month history of alanine and aspartate aminopherase elevation. Laboratory examination revealed that the serum α‑fetoprotein (AFP) level was 371.51 µg/l (normal range, 0‑20 µg/l), and a computed tomography scan revealed a hypodense lesion in the left hepatic lobe. During laparotomy, a dark red‑colored soft tumor (1.5x1.7 cm in diameter) was found in segment eight of the liver. Intra‑operative pathology and post‑operative histopathology examinations revealed that the tumor was a hepatic cavernous hemangioma. The serum AFP level was decreased to 24.45 µg/l by the second post‑operative week. The literature was searched and only three similar cases were found. A brief review of this rare disease entity was produced, which attempted to explain this appearance reasonably.

View Figures

View References

1	Ishak KG, Anthony PP, Niederau C and Nakanuma Y: Mesenchymal tumours of the liver. World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of the Digestive System. Hamilton SR and Aaltonen LA: IARC Press; Lyon, France: pp. 191–198. 2000
2	Ball D, Rose E and Alpert E: Alpha-fetoprotein levels in normal adults. Am J Med Sci. 303:157–159. 1992. View Article : Google Scholar : PubMed/NCBI
3	Abu El Makarem M: An overview of biomarkers for the diagnosis of hepatocellular carcinoma. Hepat Mon. 12:e61222012. View Article : Google Scholar : PubMed/NCBI
4	Yan D, He Q, Chen Y, Wang L and Zhang X: Detection of α-fetoprotein and glypican-3 mRNAs in the peripheral blood of hepatocellular carcinoma patients by using multiple FQ-RT-PCR. J Clin Lab Anal. 25:113–117. 2011. View Article : Google Scholar
5	Liu C, Xiao GQ, Yan LN, et al: Value of alpha-fetoprotein in association with clinicopathological features of hepatocellular carcinoma. World J Gastroenterol. 19:1811–1819. 2013. View Article : Google Scholar : PubMed/NCBI
6	Biondi A, Malaguarnera G, Vacante M, et al: Elevated serum levels of Chromogranin A in hepatocellular carcinoma. BMC Surg. 12(Suppl 1): S72012. View Article : Google Scholar : PubMed/NCBI
7	Miller RR, Champagne K and Murray RC: Primary pulmonary germ cell tumor with blastomatous differentiation. Chest. 106:1595–1596. 1994. View Article : Google Scholar : PubMed/NCBI
8	Shimada H, Noie T, Ohashi M, Oba K and Takahashi Y: Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association. Gastric Cancer. 17:26–33. 2014. View Article : Google Scholar
9	Abdel-Rahman M, Saad Y, El-Raziky M, et al: Hepatitis C genotype 4 with normal transaminases: Correlation with fibrosis and response to treatment, a cohort Egyptian study of 4277 patients. Clin Res Hepatol Gastroenterol. 37:479–484. 2013. View Article : Google Scholar : PubMed/NCBI
10	Wang L, Zhong Y, Sun L, et al: Clinical and pathological features of hepatoid carcinoma of the ovary. World J Surg Oncol. 11:292013. View Article : Google Scholar : PubMed/NCBI
11	Tong HL, Dong ZN, Wen XY, et al: Impact of chronic kidney disease on serum tumor markers concentrations. Chin Med J (Engl). 126:274–279. 2013.
12	Valentino F, Torchio M, Morbini P and Danova M: Synchronous presentation of hepatoid alpha-fetoprotein-producing lung cancer and colorectal adenocarcinoma. Tumori. 98:130e–134e. 2012.PubMed/NCBI
13	Paradies G, Zullino F, Orofino A and Leggio S: Unusual presentation of sacrococcygeal teratomas and associated malformations in children. Clinical experience and review of the literature. Ann Ital Chir. 84:333–346. 2013.
14	Han SL, Wu XL, Jia ZR and Wang PF: Adult hepatic cavernous haemangioma with highly elevated alpha-fetoprotein. Hong Kong Med J. 16:400–402. 2010.PubMed/NCBI
15	Wang ZG, Ding FQ, Zhang AL and Liu GZ: Hepatic hemangioma associated with AFP elevation: two case reports. Qilu Zhongliu Zazhi. 4:1531997.(In Chinese).
16	Visvader JE and Lindeman GJ: Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer. 8:755–768. 2008. View Article : Google Scholar : PubMed/NCBI
17	Stovold R, Blackhall F, Meredith S, et al: Biomarkers for small cell lung cancer: neuroendocrine, epithelial and circulating tumour cells. Lung Cancer. 76:263–268. 2012. View Article : Google Scholar
18	Liu J, Zheng M, Tang YL, Liang XH and Yang Q: MicroRNAs, an active and versatile group in cancers. Int J Oral Sci. 3:165–175. 2011. View Article : Google Scholar : PubMed/NCBI
19	Sasaki N, Ishii T, Kamimura R, et al: Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics. Cancer Lett. 308:152–161. 2011. View Article : Google Scholar : PubMed/NCBI
20	Wang C, Yang W, Yan HX, et al: Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice. Hepatology. 55:108–120. 2012. View Article : Google Scholar
21	Arzumanyan A, Friedman T, Ng IO, et al: Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells? Cancer Res. 71:3701–3708. 2011. View Article : Google Scholar : PubMed/NCBI
22	Sun YL, Yin SY, Xie HY, et al: Stem-like cells in hepatitis B virus-associated cirrhotic livers and adjacent tissue to hepatocellular carcinomas possess the capacity of tumorigenicity. J Gastroenterol Hepatol. 23:1280–1286. 2008. View Article : Google Scholar : PubMed/NCBI