Solitary fibrous tumor of the submandibular region

Shi,Wang; Wei,Zheng

doi:10.3892/ol.2014.2785

Solitary fibrous tumor of the submandibular region

Authors:
- Wang Shi
- Zheng Wei
View Affiliations

Affiliations: Department of Stomatology, The Third Central Hospital, Tianjin 300170, P.R. China, Department of Orthodontics, Tianjin Stomatological Hospital, Nankai University, Tianjin 300041, P.R. China
Published online on: December 9, 2014 https://doi.org/10.3892/ol.2014.2785
Pages: 984-986

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Solitary fibrous tumors (SFTs) are a rare type of neoplasm that originate from the pleura. Although SFTs may occur in a variety of extrathoracic regions, they are considered to be rare in the submandibular region. The current study presents the case of a 39‑year‑old female with a 3x4‑cm, fibro‑elastic, movable, painless nodule in the right side of the submandibular region. The patient exhibited no other clinical manifestations in the head and neck region. A computed tomography scan demonstrated the presence of a well‑defined, slightly low‑density nodular shadow measuring 2.6x3.3x3.8 cm, in proximity to the right submandibular gland, with mild contrast enhancement and no association with the adjacent lymph nodes. The lesion was surgically excised, and following histopathological and immunohistochemical analysis, immunohistochemical staining determined that the lesion was positive for cluster of differentiation (CD)34, CD99 and vimentin, and negative for desmin, CD31 and S‑100; therefore, a diagnosis of an SFT was determined. The patient has so far been followed up for 22 months, with no signs of recurrence or metastases. The present study also discusses the clinical, histopathological and immunohistochemical features, treatment strategies and potential clinical outcomes of SFTs. The study proposes that, although rare, SFTs of the submandibular region should be included in the differential diagnosis of soft‑tissue tumors in the submandibular region.

View Figures

View References

1	Klemperer P and Coleman BR: Primary neoplasm of the pleura. A report of five cases. Am J Ind Med. 11:1–31. 1931.
2	Gengler C and Guillou L: Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology. 48:63–74. 2006. View Article : Google Scholar
3	Kim HJ, Lee HK, Seo JJ, Kim HJ, Shin JH, Jeong AK, Lee JH and Cho KJ: MR imaging of solitary fibrous tumors in the head and neck. Korean J Radiol. 6:136–142. 2005. View Article : Google Scholar : PubMed/NCBI
4	Garg D, Palaskar S, Shetty VP, Bhushan A, Bhatia P and Sarin J: Diagnostic dilemma: solitary fibrous tumor or hemangiopericytoma of the submandibular region in a patient with multiple odontogenic keratocysts. J Pediatr Oncol Nurs. 26:136–141. 2009. View Article : Google Scholar : PubMed/NCBI
5	Hofmann T, Braun H, Köle W and Beham A: Solitary fibrous tumor of the submandibular gland. Eur Arch Otorhinolaryngol. 259:470–473. 2002.PubMed/NCBI
6	Fu CH, Ueng SH, Shao PY and Chang KP: Pathology quiz case 1: solitary fibrous tumor (SFT) of the submandibular gland. Arch Otolaryngol Head Neck Surg. 134:214–216. 2008. View Article : Google Scholar : PubMed/NCBI
7	Battifora H and McCaughey WTE: Tumors of the serosal membranes. Atlas of Tumor Pathology 3rd series, fascicle 15. Armed Forces Institute of Pathology; Washington, DC: pp. 101–109. 1995
8	Hanau CA and Miettinen M: Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol. 26:440–449. 1995. View Article : Google Scholar : PubMed/NCBI
9	Fletcher CD: The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology. 48:3–12. 2006. View Article : Google Scholar
10	Bortolotti U, Calabrò F, Loy M, Fasoli G, Altavilla G and Marchese D: Giant intrapericardial solitary fibrous tumor. Ann Thorac Surg. 54:1219–1220. 1992. View Article : Google Scholar : PubMed/NCBI
11	Magro G, Emmanuele C, Lopes M, Vallone G and Greco P: Solitary fibrous tumour of the kidney with sarcomatous overgrowth. Case report and review of the literature. APMIS. 116:1020–1025. 2008. View Article : Google Scholar
12	Ha JK, Park BJ, Kim YH and Lim YJ: Orbital solitary fibrous tumor: a case report and diagnostic clues. J Korean Neurosurg Soc. 46:77–80. 2009. View Article : Google Scholar : PubMed/NCBI
13	Brunnemann RB, Ro JY, Ordonez NG, Mooney J, El-Naggar AK and Ayala AG: Extrapleural solitary fibrous tumor: a clinicopathologic study of 24 cases. Mod Pathol. 12:1034–1042. 1999.PubMed/NCBI
14	Morgan MB and Smoller BR: Solitary fibrous tumors are immunophenotypically distinct from mesothelioma(s). J Cutan Pathol. 27:451–454. 2000. View Article : Google Scholar : PubMed/NCBI
15	de Saint Aubain Somerhausen N, Rubin BP and Fletcher CD: Myxoid solitary fibrous tumor: a study of seven cases with emphasis on differential diagnosis. Mod Pathol. 12:463–471. 1999.PubMed/NCBI
16	Thompson LD, Karamurzin Y, Wu ML and Kim JH: Solitary fibrous tumor of the larynx. Head Neck Pathol. 2:67–74. 2008. View Article : Google Scholar : PubMed/NCBI
17	Sandvliet RH, Heysteeg M and Paul MA: A large thoracic mass in a 57-year-old patient. Solitary fibrous tumor of the pleura. Chest. 117:897–900. 2000. View Article : Google Scholar : PubMed/NCBI
18	Gold JS, Antonescu CR, Hajdu C, Ferrone CR, Hussain M, Lewis JJ, Brennan MF and Coit DG: Clinicopathologic correlates of solitary fibrous tumors. Cancer. 94:1057–1068. 2002. View Article : Google Scholar : PubMed/NCBI
19	Flint PW, Haughley BH, Lund VJ, et al: Cummings Otolaryngology-Head and Neck Surgery. 5th edition. Mosby, Elsevier; Philadelphia, PA: 2010
20	Bauer JL, Miklos AZ and Thompson LD: Parotid gland solitary fibrous tumor: a case report and clinicopathologic review of 22 cases from the literature. Head Neck Pathol. 6:21–31. 2012. View Article : Google Scholar :
21	Hirano D, Mashiko A, Murata Y, Satoh K, Ichinose T, Takahashi S, Jike T and Sugitani M: A case of solitary fibrous tumor of the kidney: an immunohistochemical and ultrastructural study with a review of the literature. Med Mol Morphol. 42:239–244. 2009. View Article : Google Scholar : PubMed/NCBI
22	Alobid I, Alós L, Maldonado M, Menéndez LM and Bernal-Sprekelsen M: Laryngeal solitary fibrous tumor treated with CO₂ laser excision: case report. Eur Arch Otorhinolaryngol. 262:286–288. 2005. View Article : Google Scholar
23	Sousa AA, Souto GR, Sousa IA, Mesquita RA, Gomez RS and Jham BC: Solitary fibrous tumor of the parotid gland: Case report. J Clin Exp Dent. 5:e208–e211. 2013. View Article : Google Scholar
24	Yang XJ, Zheng JW, Ye WM, et al: Malignant solitary fibrous tumors of the head and neck: a clinicopathological study of nine consecutive patients. Oral Oncol. 45:678–682. 2009. View Article : Google Scholar : PubMed/NCBI
25	Goodlad JR and Fletcher CD: Solitary fibrous tumour arising at unusual sites: analysis of a series. Histopathology. 19:515–522. 1991. View Article : Google Scholar : PubMed/NCBI
26	Cox DP, Daniels T and Jordan RC: Solitary fibrous tumor of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 110:79–84. 2010. View Article : Google Scholar : PubMed/NCBI
27	Suster S, Nascimento AG, Miettinen M, Sickel JZ and Moran CA: Solitary fibrous tumors of soft tissue. A clinicopathologic and immunohistochemical study of 12 cases. Am J Surg Pathol. 19:1257–1266. 1995. View Article : Google Scholar : PubMed/NCBI