Emerging role of microRNA in hepatocellular carcinoma (Review)

  • Authors:
    • Jin Gong
    • Xing-Xing He
    • De-An Tian
  • View Affiliations

  • Published online on: December 19, 2014     https://doi.org/10.3892/ol.2014.2816
  • Pages: 1027-1033
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Abstract

Hepatocellular carcinoma is a type of cancer characterized by significant morbidity and high mortality rates worldwide. Previous studies have revealed that alterations in microRNA (miRNA) expression are a common feature of cancer. Furthermore, as evolutionarily conserved, non‑encoding RNAs, miRNAs have demonstrated fundamental roles in the various biological processes involved in cancer. Genome‑wide miRNA expression profile studies and bioinformatic methods have provided comprehensive insight into the role of cancer‑related miRNAs. In addition, investigation of the function and mechanisms of miRNAs has provided an understanding of the association with the pathogenesis of cancer. In the present review, the tumor‑promoting or tumor‑suppressive roles and underlying mechanisms of certain significant miRNAs at a single and integral level are summarized. Furthermore, the recognition of miRNA‑gene networks and current advances in the potential use of miRNA‑based diagnosis and therapy are discussed.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Gong J, He X and Tian D: Emerging role of microRNA in hepatocellular carcinoma (Review). Oncol Lett 9: 1027-1033, 2015.
APA
Gong, J., He, X., & Tian, D. (2015). Emerging role of microRNA in hepatocellular carcinoma (Review). Oncology Letters, 9, 1027-1033. https://doi.org/10.3892/ol.2014.2816
MLA
Gong, J., He, X., Tian, D."Emerging role of microRNA in hepatocellular carcinoma (Review)". Oncology Letters 9.3 (2015): 1027-1033.
Chicago
Gong, J., He, X., Tian, D."Emerging role of microRNA in hepatocellular carcinoma (Review)". Oncology Letters 9, no. 3 (2015): 1027-1033. https://doi.org/10.3892/ol.2014.2816