Primary non-Hodgkin's lymphoma of the prostate with intractable hematuria: A case report and review of the literature

Hu,Shanbiao; Wang,Yinhuai; Yang,Luoyan; Yi,Lu; Nian,Yeqi

doi:10.3892/ol.2014.2829

Primary non-Hodgkin's lymphoma of the prostate with intractable hematuria: A case report and review of the literature

Authors:
- Shanbiao Hu
- Yinhuai Wang
- Luoyan Yang
- Lu Yi
- Yeqi Nian
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Affiliations: Department of Urology, Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China
Published online on: December 24, 2014 https://doi.org/10.3892/ol.2014.2829
Pages: 1187-1190

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Abstract

Cases of primary non‑Hodgkin's lymphoma of the prostate are globally rare. The present study reports a case of prostatic diffuse large B‑cell lymphoma (DLBCL) with intractable hematuria in a 75‑year‑old male. The patient presented with difficulties in urination and gross hematuria. A prostate biopsy was performed immediately, followed by conservative treatment for bleeding. A bilateral iliac arteriography and chemoembolization were then performed as emergency procedures under local anesthesia due to significant bleeding and a sharply decreased blood pressure, indicating the failure of the conservative treatment. Consequently, the bleeding was effectively controlled. Pathological examination of the prostate biopsy confirmed the presence of a DLBCL of non‑germinal center B‑cell origin. Immunohistochemical examination demonstrated cluster of differentiation (CD)20(++), CD3(+), leukocyte common antigen(+++), B‑cell lymphoma‑2(+) and prostate‑specific antigen(‑) results. Due to the poor general condition and low hemoglobin levels of the patient, a low‑dose Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R‑CHOP) chemotherapy regimen was administered. Subsequent to three courses of chemotherapy, the patient achieved complete remission. In conclusion, combining R‑CHOP and bilateral selective iliac arterial chemoembolization could be a safe and effective way to treat patients with non‑Hodgkin's lymphoma of the prostate and intractable hematuria.

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