Sarcoidosis in gastric cancer at the time of diagnosis: A case report

Jiao,Yang; Ning,Jie; Zhao,Wen‑Di; Li,Yan‑Li; Wu,Hong‑Yang; Gu,Kang‑Sheng

doi:10.3892/ol.2015.2850

Sarcoidosis in gastric cancer at the time of diagnosis: A case report

Authors:
- Yang Jiao
- Jie Ning
- Wen‑Di Zhao
- Yan‑Li Li
- Hong‑Yang Wu
- Kang‑Sheng Gu
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Affiliations: Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China
Published online on: January 5, 2015 https://doi.org/10.3892/ol.2015.2850
Pages: 1159-1162

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Abstract

Sarcoidosis is a multisystemic inflammatory disease that commonly affects the lungs and lymphatic system and is characterized by the formation of non‑caseating granulomas. Although the association between sarcoidosis and malignant diseases has been well described, it remains controversial whether this association is merely a coincidence or the consequence of a common pathophysiological mechanism. The present study reports a rare case of sarcoidosis that was present in a patient with gastric cancer at the time of diagnosis. A 64‑year‑old female diagnosed with stage Ⅰ gastric cancer underwent curative surgery, and the postoperative pathology of the lymph nodes revealed non‑caseating granulomas. At the 4‑year follow‑up, the sarcoidosis remained stable, and no recurrence of cancer was identified. The present case revealed that sarcoidosis and gastric cancer may coexist simultaneously and focused on the potential advantages of histological confirmation in patients with cancer and sarcoidosis.

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1	Newman LS, Rose CS and Maier LA: Sarcoidosis. N Engl J Med. 336:1224–1234. 1997. View Article : Google Scholar : PubMed/NCBI
2	Wu JJ and Schiff KR: Sarcoidosis. Am Fam Physician. 70:312–322. 2004.PubMed/NCBI
3	Sato Y, Sasano S, Oyama K, Sakuraba M, Onuki T and Nitta S: Lung cancer associated with sarcoidosis. Jpn J Thorac Cardiovasc Surg. 51:21–24. 2003. View Article : Google Scholar : PubMed/NCBI
4	Bouros D, Hatzakis K, Labrakis H and Zeibecoglou K: Association of malignancy with diseases causing interstitial pulmonary changes. Chest. 121:1278–1289. 2002. View Article : Google Scholar : PubMed/NCBI
5	Scott HW Jr and Weidner MG: Total gastrectomy with Roux-en-Y esophagojejunostomy in treatment of gastric cancer. Ann Surg. 143:682–696. 1956. View Article : Google Scholar : PubMed/NCBI
6	Sobin LH, Gospodarowicz MK and Wittekind C: TNM classification of malignant tumours. 7th edition. Wiley; New York, NY: 2009
7	NCCN Guidelines version 1.2014 Panel Members Gastric Cancer. https://www.nccn.org/store/login/login.aspx?ReturnURL=http://www.nccn.org/professionals/physician_gls/pdf/gastric.pdf. Accessed May 30, 2014
8	Tolaney SM, Colson YL, Gill RR, et al: Sarcoidosis mimicking metastatic breast cancer. Clin Breast Cancer. 7:804–810. 2007. View Article : Google Scholar : PubMed/NCBI
9	Bush E, Lamonica D and O’Connor T: Sarcoidosis mimicking metastatic breast cancer. Breast J. 17:533–535. 2011. View Article : Google Scholar : PubMed/NCBI
10	Shin HC, Choe JW, Ryu HS, et al: Sarcoidosis mimicking metastatic breast cancer in Korean woman with breast cancer. Breast J. 20:198–199. 2014. View Article : Google Scholar : PubMed/NCBI
11	Maeda J, Ohta M, Hirabayashi H and Matsuda H: False positive accumulation in 18F fluorodeoxyglucose positron emission tomography scan due to sarcoid reaction following induction chemotherapy for lung cancer. Jpn J Thorac Cardiovasc Surg. 53:196–198. 2005. View Article : Google Scholar : PubMed/NCBI
12	Umezu H, Chida M, Inoue T, et al: Sarcoidosis development during induction chemotherapy for lung cancer mimicked progressive disease. Gen Thorac Cardiovasc Surg. 58:434–437. 2010. View Article : Google Scholar : PubMed/NCBI
13	Kim JJ, Park JK, Wang YP, Choi SH and Jo KH: Lung cancer associated with sarcoidosis -A case report-. Korean J Thorac Cardiovasc Surg. 44:301–303. 2011. View Article : Google Scholar
14	Kyoraku Y, Ashitani J, Sakamoto A, Yanagi S, Matsumoto N and Nakazato M: A case of Hodgkin’s lymphoma in a patient with sarcoidosis. Nihon Kokyuki Gakkai Zasshi. 47:900–905. 2009.(In Japanese). PubMed/NCBI
15	Cherk MH, Pham A and Haydon A: 18F-fluorodeoxyglucose positron emission tomography-positive sarcoidosis after chemoradiotherapy for Hodgkin’s disease: a case report. J Med Case Rep. 29:2472011. View Article : Google Scholar
16	Kalff V, Hicks RJ, Ware RE, Hogg A, Binns D and McKenzie AF: The clinical impact of (18)F-FDG PET in patients with suspected or confirmed recurrence of colorectal cancer: a prospective study. J Nucl Med. 43:492–499. 2002.PubMed/NCBI
17	Lequoy M, Coriat R, Rouquette A, et al: Sarcoidosis lung nodules in colorectal cancer follow-up: sarcoidosis or not? Am J Med. 126:642–645. 2013. View Article : Google Scholar : PubMed/NCBI
18	Choi JH, Shin JA, Park HK, et al: Sarcoidosis associated with oxaliplatin-based chemotherapy for colorectal cancer. Case Rep Oncol Med. 2014:2030272014.PubMed/NCBI
19	Yao M, Funk GF, Goldstein DP, DeYoung BR and Graham MM: Benign lesions in cancer patients. Case 1 Sarcoidosis after chemoradiation for head and neck cancer. J Clin Oncol. 23:640–641. 2005. View Article : Google Scholar : PubMed/NCBI
20	Arana Yi C, McCue P, Rosen M, Machtay M, Axelrod R and Morris GJ: Sarcoidosis mimicking metastatic bone disease in head and neck cancer. Semin Oncol. 40:529–534. 2013. View Article : Google Scholar : PubMed/NCBI
21	Hendrickx BW, van Herpen CM, Bonenkamp JJ, Bulten J and Oyen WJ: Positive positron emission tomography scan in sarcoidosis and two challenging cases of metastatic cancer. CASE 1 Mediastinal sarcoidosis in a melanoma patient treated with interferon. J Clin Oncol. 23:8906–8907. 2005. View Article : Google Scholar : PubMed/NCBI
22	Wilgenhof S, Morlion V, Seghers AC, et al: Sarcoidosis in a patient with metastatic melanoma sequentially treated with anti-CTLA-4 monoclonal antibody and selective BRAF Inhibitor. Anticancer Res. 32:1355–1359. 2012.PubMed/NCBI
23	Vogel WV, Guislain A, Kvistborg P, Schumacher TN, Haanen JB and Blank CU: Ipilimumab-induced sarcoidosis in a patient with metastatic melanoma undergoing complete remission. J Clin Oncol. 30:e7–e10. 2012. View Article : Google Scholar
24	Kim MH, Lee K, Kim KU, Park HK, Lee MK and Suh DS: Sarcoidosis mimicking cancer metastasis following chemotherapy for ovarian cancer. Cancer Res Treat. 45:354–358. 2013. View Article : Google Scholar
25	Konishi H, Komatsu S, Ichikawa D, et al: Diagnostic problems in gastric cancer patients with sarcoidosis - case report and literature review. Gan To Kagaku Ryoho. 39:2330–2332. 2012.PubMed/NCBI
26	Blank N, Lorenz HM, Ho AD and Witzens-Harig M: Sarcoidosis and the occurrence of malignant diseases. Rheumatol Int. 2014.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI
27	Brincker H and Wilbek E: The incidence of malignant tumors in patients with sarcoidosis. Ugeskr Laeger. 136:2192–2195. 1974.(In Danish). PubMed/NCBI
28	Yamaguchi M, Odaka M, Hosoda Y, Iwai K and Tachibana T: Excess death of lung cancer among sarcoidosis patients. Sarcoidosis. 8:51–55. 1991.PubMed/NCBI
29	Askling J, Grunewald J, Eklund A, Hillerdal G and Ekbom A: Increased risk for cancer following sarcoidosis. Am J Respir Crit Care Med. 160:1668–1672. 1999. View Article : Google Scholar : PubMed/NCBI
30	Boffetta P, Rabkin CS and Gridley G: A cohort study of cancer among sarcoidosis patients. Int J Cancer. 124:2697–2700. 2009. View Article : Google Scholar : PubMed/NCBI
31	Ji J, Shu X, Li X, Sundquist K, Sundquist J and Hemminki K: Cancer risk in hospitalized sarcoidosis patients: a follow-up study in Sweden. Ann Oncol. 20:1121–1126. 2009. View Article : Google Scholar : PubMed/NCBI
32	Suen JS, Forse MS, Hyland RH and Chan CK: The malignancy-sarcoidosis syndrome. Chest. 98:1300–1302. 1990. View Article : Google Scholar : PubMed/NCBI
33	Rømer FK, Hommelgaard P and Schou G: Sarcoidosis and cancer revisited: a long-term follow-up study of 555 Danish sarcoidosis patients. Eur Respir J. 12:906–912. 1998. View Article : Google Scholar : PubMed/NCBI
34	Seersholm N, Vestbo J and Viskum K: Risk of malignant neoplasms in patients with pulmonary sarcoidosis. Thorax. 52:892–894. 1997. View Article : Google Scholar : PubMed/NCBI