Successful management of acute myeloid leukemia transformed from chronic myelomonocytic leukemia in the elderly by a combination regimen of decitabine and cytarabine, aclarubicin and granulocyte colony-stimulating factor: A case report

  • Authors:
    • Qi Deng
    • Jing‑Yi Li
    • Peng‑Jiang Liu
    • Ming‑Feng Zhao
  • View Affiliations

  • Published online on: January 13, 2015     https://doi.org/10.3892/ol.2015.2870
  • Pages: 1217-1220
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Abstract

Despite advances in the treatment of acute myeloid leukemia (AML) in recent years, the outcome of elderly AML patients with antecedent hematological disorders remains unsatisfactory. The present study describes a case of complete remission in an elderly patient with AML transformed from chronic myelomonocytic leukemia (CMML) and the treatment of the case with decitabine in combination with cytarabine, aclarubicin and granulocyte colony‑stimulating factor (CAG). A 70‑year‑old male was admitted with fever, pruritus and weakness that had been apparent for two weeks, and a two‑year history of monocytosis (22.5‑27.0%). Further examinations revealed a hemoglobin level of 106 g/l, a white blood cell count of 39.52x109/l, a platelet count of 81x109/l, Y chromosome loss and uniparental disomy on chromosomes 4q, 2q and 19p. The patient was diagnosed with AML transformed from CMML, with cytogenetic anomalies. A combination regimen of decitabine and CAG was administered. Subsequent to one cycle, the patient achieved complete remission. The patient was then followed up with three courses of the same regimen and achieved clinical remission, with no evidence of AML relapse. The present study suggests that a combination of low‑dose decitabine and CAG may offer a novel and potentially effective treatment regimen for elderly AML patients.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Deng Q, Li JY, Liu PJ and Zhao MF: Successful management of acute myeloid leukemia transformed from chronic myelomonocytic leukemia in the elderly by a combination regimen of decitabine and cytarabine, aclarubicin and granulocyte colony-stimulating factor: A case report. Oncol Lett 9: 1217-1220, 2015.
APA
Deng, Q., Li, J., Liu, P., & Zhao, M. (2015). Successful management of acute myeloid leukemia transformed from chronic myelomonocytic leukemia in the elderly by a combination regimen of decitabine and cytarabine, aclarubicin and granulocyte colony-stimulating factor: A case report. Oncology Letters, 9, 1217-1220. https://doi.org/10.3892/ol.2015.2870
MLA
Deng, Q., Li, J., Liu, P., Zhao, M."Successful management of acute myeloid leukemia transformed from chronic myelomonocytic leukemia in the elderly by a combination regimen of decitabine and cytarabine, aclarubicin and granulocyte colony-stimulating factor: A case report". Oncology Letters 9.3 (2015): 1217-1220.
Chicago
Deng, Q., Li, J., Liu, P., Zhao, M."Successful management of acute myeloid leukemia transformed from chronic myelomonocytic leukemia in the elderly by a combination regimen of decitabine and cytarabine, aclarubicin and granulocyte colony-stimulating factor: A case report". Oncology Letters 9, no. 3 (2015): 1217-1220. https://doi.org/10.3892/ol.2015.2870