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Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature

  • Authors:
    • Fei Yan
    • Yanli Ma
    • Jianhai Sun
    • Pengcheng Zhu

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  • Published online on: January 16, 2015     https://doi.org/10.3892/ol.2015.2882
  • Pages: 1343-1346
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Abstract

Reactive nodular fibrous pseudotumor (RNFP) is a tumor‑like lesion that is characterized by reactive fibroblast/myofibroblast proliferation within collagenic hyalinized stroma, due to its association with injury or inflammation. The current study describes the case of a 60‑year‑old female with a history of abdominal surgery and abdominal pain. Upon laparoscopy, multiple nodules attached to the outer layer of the colon and mesentery were identified, and therefore, complete surgical excision was performed. Macroscopically, the nodules were well‑circumscribed, firm, tan‑white in color and ranged in size between 2.0‑10.0 cm at the greatest dimension. Microscopically, the nodules were composed of spindle and stellate cells in a dense collagenic hyalinized background with sparse lymphocytic infiltration. Immunohistochemical analysis demonstrated positive staining for vimentin, smooth muscle actin and cluster of differentiation (CD) 117, and focally‑positive keratin staining with AE1/AE3; however, no staining was observed for gastrointestinal stromal tumor 1, CD34, S‑100, anaplastic lymphoma kinase or β‑catenin. Therefore, it was proposed that the lesion may be most accurately described as an RNFP. The current study reports a rare case of RNFP, emphasizing its histopathological features and differential diagnoses to promote an improved and broader understanding of this poorly understood condition.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • Impact Factor: 2.5
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  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
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Spandidos Publications style
Yan F, Ma Y, Sun J and Zhu P: Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature. Oncol Lett 9: 1343-1346, 2015.
APA
Yan, F., Ma, Y., Sun, J., & Zhu, P. (2015). Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature. Oncology Letters, 9, 1343-1346. https://doi.org/10.3892/ol.2015.2882
MLA
Yan, F., Ma, Y., Sun, J., Zhu, P."Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature". Oncology Letters 9.3 (2015): 1343-1346.
Chicago
Yan, F., Ma, Y., Sun, J., Zhu, P."Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature". Oncology Letters 9, no. 3 (2015): 1343-1346. https://doi.org/10.3892/ol.2015.2882