Androgen receptor in hepatocarcinogenesis: Recent developments and perspectives (Review)

  • Authors:
    • Ye Tian
    • Xu Xie
    • Yao Lin
    • Guang Tan
    • Wu Zhong
  • View Affiliations

  • Published online on: March 10, 2015     https://doi.org/10.3892/ol.2015.3025
  • Pages: 1983-1988
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Previous studies have indicated that males are at a higher risk of developing hepatocellular carcinoma (HCC) compared with females. Identifying the factors that cause this gender‑specific difference in the incidence of HCC has long been considered important for revealing the molecular mechanisms involved in hepatocarcinogenesis. Given the unprecedented tools that are now available for molecular research, genetic studies have established that the androgen receptor (AR) may be partly responsible for gender disparity in HCC. AR has a dual role, promoting HCC initiation and development, as well as suppressing HCC metastasis. The present review provides an overview of the involvement of AR signaling in HCC. The review highlighted important studies, examples of the direct AR transcriptional target genes involved in HCC and novel theories concerning the conventional concept, suggesting that targeting the AR, rather than the androgen, may provide an improved therapeutic approach for the treatment of HCC.
View Figures
View References

Related Articles

Journal Cover

May-2015
Volume 9 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tian Y, Xie X, Lin Y, Tan G and Zhong W: Androgen receptor in hepatocarcinogenesis: Recent developments and perspectives (Review). Oncol Lett 9: 1983-1988, 2015.
APA
Tian, Y., Xie, X., Lin, Y., Tan, G., & Zhong, W. (2015). Androgen receptor in hepatocarcinogenesis: Recent developments and perspectives (Review). Oncology Letters, 9, 1983-1988. https://doi.org/10.3892/ol.2015.3025
MLA
Tian, Y., Xie, X., Lin, Y., Tan, G., Zhong, W."Androgen receptor in hepatocarcinogenesis: Recent developments and perspectives (Review)". Oncology Letters 9.5 (2015): 1983-1988.
Chicago
Tian, Y., Xie, X., Lin, Y., Tan, G., Zhong, W."Androgen receptor in hepatocarcinogenesis: Recent developments and perspectives (Review)". Oncology Letters 9, no. 5 (2015): 1983-1988. https://doi.org/10.3892/ol.2015.3025