Clinical characteristics and laboratory analyses of acute myeloid leukemia with t(16;21)(p11;q22)

Zhang,Zhifen; Zou,Jianwen; Li,Yuantang; Liu,Zhanfeng; Xu,Rui; Tian,Wenjun; Zhao,Zongchen; Sun,Hui; Han,Jingying; Wang,Jia; Zhang,Bingchang; Ju,Ying

doi:10.3892/ol.2015.3051

May-2015 Volume 9 Issue 5

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May-2015 Volume 9 Issue 5

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Article

Clinical characteristics and laboratory analyses of acute myeloid leukemia with t(16;21)(p11;q22)

Authors:
- Zhifen Zhang
- Jianwen Zou
- Yuantang Li
- Zhanfeng Liu
- Rui Xu
- Wenjun Tian
- Zongchen Zhao
- Hui Sun
- Jingying Han
- Jia Wang
- Bingchang Zhang
- Ying Ju
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
Pages: 2244-2248
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Published online on: March 17, 2015

https://doi.org/10.3892/ol.2015.3051
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Abstract

The present study reviewed three patients with acute myeloid leukemia (AML) who had the specific genetic abnormality t(16;21)(p11;q22). To investigate the clinical and laboratory characteristics of AML with t(16;21)(p11;q22) translocation, the similarities and differences of clinical characteristics and laboratory examinations were compared, and a literature review was conducted. According to the French‑American‑British classification system, patient 1 was M4, patient 2 was M1 and patient 3 was M2. The cytogenetic aberrations were 46, XY, t(16;21)(p11;q22)/47, idem, +21 for patient 1 and 46, XX, t(16;21)(p11;q22) for patients 2 and 3. Cytophagocytosis and cluster of differentiation 56 antigen expression were found in all three cases. The prognosis was poor in all the cases. AML with t(16;21)(p11;q22) is a specific subtype of AML that exhibits unique characteristics of morphology, immunology, cytogenetics and clinical features, as well as a poor prognosis. Stem cell transplantation may be the first and only choice for treatment.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical characteristics and laboratory analyses of acute myeloid leukemia with t(16;21)(p11;q22)

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Abstract

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