Expression and clinical significance of mammalian target of rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma tissue

  • Authors:
    • Qingjun Lu
    • Jieshu Wang
    • Gang Yu
    • Tianhua Guo
    • Chun Hu
    • Peng Ren
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  • Published online on: May 19, 2015     https://doi.org/10.3892/ol.2015.3228
  • Pages: 277-282
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Abstract

The activation of mammalian target of rapamycin (mTOR) has been reported in tumor development, but the role of mTOR in colorectal carcinomas remains unclear. The aim of the present study was to investigate the significance of mTOR and its downstream effector 70 kDa ribosomal protein S6 kinase (P70S6K) in human colorectal carcinomas. The phosphorylated (p‑)mTOR and p‑P70S6K proteins were examined by immunohistochemistry performed on tissue microarray containing tissue samples obtained from colorectal carcinoma (n=111), adenomatous polyps (n=40) and normal colonic mucosa (n=40), with a comparison between the expression of these proteins and the clinicopathological parameters of patients with carcinomas. The positive expression rates of p‑mTOR and p‑P70S6k were 60.4 and 65.8%, respectively, in colorectal carcinoma tissue, which was significantly increased compared with the tissue from adenomatous polyps (27.5 and 20%, respectively) and normal colonic mucosa (10.0 and 5.0%, respectively) (P<0.05). Overexpression of the p‑mTOR and p‑P70S6K proteins was significantly associated with the tumor‑node‑metastasis stage, the occurrence of distal and lymph node metastasis and the degree of differentiation. Aberrant expression of p‑mTOR and p‑P70S6K may contribute to the pathogenesis, growth, invasion and metastasis of colorectal carcinoma. The phosphorylation of these proteins was considered to be a promising marker to indicate the aggressive behaviors and prognosis of colorectal carcinomas. The overexpression of the mTOR/P70S6K signaling pathway may play an important role in colorectal carcinoma carcinogenesis. The expression of p‑mTOR and p‑P70S6K was considered as a promising marker to indicate the aggressive behaviors and prognosis of human colorectal carcinomas.
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July-2015
Volume 10 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lu Q, Wang J, Yu G, Guo T, Hu C and Ren P: Expression and clinical significance of mammalian target of rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma tissue. Oncol Lett 10: 277-282, 2015.
APA
Lu, Q., Wang, J., Yu, G., Guo, T., Hu, C., & Ren, P. (2015). Expression and clinical significance of mammalian target of rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma tissue. Oncology Letters, 10, 277-282. https://doi.org/10.3892/ol.2015.3228
MLA
Lu, Q., Wang, J., Yu, G., Guo, T., Hu, C., Ren, P."Expression and clinical significance of mammalian target of rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma tissue". Oncology Letters 10.1 (2015): 277-282.
Chicago
Lu, Q., Wang, J., Yu, G., Guo, T., Hu, C., Ren, P."Expression and clinical significance of mammalian target of rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma tissue". Oncology Letters 10, no. 1 (2015): 277-282. https://doi.org/10.3892/ol.2015.3228