Combined therapy against recurrent and intracranial invasion of sinonasal hemangiopericytoma: A case report
- Authors:
- Xiaohong Wang
- Jiangong Wang
- Wanning Hu
- Lei Wang
- Yufeng Li
View Affiliations
Affiliations: Department of Medical Oncology, Tangshan People's Hospital, Tangshan, Hebei 063001, P.R. China, The Cancer Institute, Tangshan People's Hospital, Tangshan, Hebei 063001, P.R. China, Department of Pathology, Tangshan People's Hospital, Tangshan, Hebei 063001, P.R. China
- Published online on: May 20, 2015 https://doi.org/10.3892/ol.2015.3236
-
Pages:
287-290
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
Sinonasal hemangiopericytoma (HPC) is a soft tissue tumor of vascular origin. Open surgical methods and endoscopic techniques are considered the standard treatments for sinonasal HPC. However, local recurrences resulting from residual tumors are common. Adjuvant radiotherapy and chemotherapy have also been used to treat HPC, however, the number of studies which have investigated effective adjuvant treatments in the literature are limited. The current study reports a 42‑year‑old male with recurrent and intracranial invasion of sinonasal HPC, diagnosed in Xuanwu Hospital (Beijing, China). The patient underwent multiple surgeries to remove the tumors, however, no adjuvant therapy was adopted during this period and the tumors reoccurred within 1 year. On admittance to Tangshan People's Hospital (Tangshan, China), the patient presented with limited mouth opening and chewing ability, and hearing loss. Under observation using an electron microscope, HPC usually consists of spindle‑shaped cells with elongated nuclei and displays characteristic staghorn‑like vascular channels. In the present case, immunohistochemical studies were performed on paraffin‑embedded sections of the tumor. The tumor cells expressed CD34, CD68(+/‑), epithelial membrane antigen, CD31, α‑actin, desmin, CD99, S‑100, B‑cell lymphoma‑2 and Ki‑67 (30%), but were negative for creatine kinase. The patient was treated with intensity‑modulated radiotherapy and adjuvant chemotherapy, which demonstrated efficacy. No recurrence and metastasis was observed at the 1 year follow‑up subsequent to the combined therapy.
View References
1
|
Billings KR, Fu YS, Calcaterra TC and
Sercarz JA: Hemangiopericytoma of the head and neck. Am J
Otolaryngol. 21:238–243. 2000. View Article : Google Scholar : PubMed/NCBI
|
2
|
Terada T and Kato T: Sinonasal-type
hemangiopericytoma of the nasal cavity and paranasal sinus. Int J
Clin Oncol. 17:169–173. 2012. View Article : Google Scholar : PubMed/NCBI
|
3
|
Duman FU, Ayhan S, Işısağ A, Eskıızmır G
and Tarhan S: Sinonasal-type haemangiopericytoma: A case report.
Turk Patoloji Derg. Mar 18–2014.(Epub ahead of print) (In
Turkish).
|
4
|
Dahodwala MQ, Husain Q, Kanumuri VV,
Choudhry OJ, Liu JK and Eloy JA: Management of sinonasal
hemangiopericytomas: a systematic review. Int Forum Allergy Rhinol.
2013.3(7): 581–7. View Article : Google Scholar : PubMed/NCBI
|
5
|
Thompson LD, Miettinen M and Wenig BM:
Sinonasal-type hemangiopericytoma: a clinicopathologic and
immunophenotypic analysis of 104 cases showing perivascular myoid
differentiation. Am J Surg Patho1. 27:737–749. 2003. View Article : Google Scholar
|
6
|
Fletcher CD1: Distinctive soft tissue
tumors of the head and neck. Mod Pathol. 2002.15(3): 324–30.
View Article : Google Scholar : PubMed/NCBI
|
7
|
Agaimy A1, Barthelmeß S, Geddert H, Boltze
C, Moskalev EA, Koch M, Wiemann S, Hartmann A and Haller F:
Phenotypical and molecular distinctness of sinonasal
haemangiopericytoma compared to solitary fibrous tumour of the
sinonasal tract. Histopathology. 2014.65(5): 667–73. View Article : Google Scholar : PubMed/NCBI
|
8
|
Yokoi H, Arakawa A, Kuribayashi K,
Inoshita A, Haruyama T and Ikeda K: An immunohistochemical study of
sinonasal hemangiopericytoma. Auris Nasus Larynx. 38:743–746. 2011.
View Article : Google Scholar : PubMed/NCBI
|
9
|
Illuminati G, Pizzardi G, Calio F, Pacilè
MA, Carboni F, Palumbo P and Vietri F: Hemangiopericytoma of the
spleen. Int J Surg. 15:6–10. 2015. View Article : Google Scholar : PubMed/NCBI
|
10
|
Iwamuro M, Nakamura S, Shiraha H, et al: A
case of primary intracranial hemangiopericytoma with hepatic
metastases: successful treatment with radiofrequency ablation and
transcatheter arterial chemoembolization. Clin J Gastroenterol.
2:30–35. 2009. View Article : Google Scholar
|
11
|
Maria PS, Mauri M and Carmignani L: A
unique cause of hemoperitoneum: spontaneous rupture of a splenic
hemangiopericytoma. Int J Emerg Med. 4:132011. View Article : Google Scholar : PubMed/NCBI
|