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Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study

  • Authors:
    • Shangtong Lei
    • Zihai Ding
    • Junna Ge
    • Donghui Zhao

  • View Affiliations

  • Published online on: June 24, 2015     https://doi.org/10.3892/ol.2015.3416
  • Pages: 1749-1754
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Differentiated thyroid carcinoma (DTC) is one of the most common metabolic disorders and accounts for 98% of all cases of thyroid cancer. Previously, a number of studies have investigated the prognostic factors associated with well‑differentiated thyroid carcinoma (WDTC); however, these studies yielded conflicting results. The current study used a retrospective study design to collect data from WDTC patients who had received the same treatment regimen from the same institute, with a minimum follow‑up of 10 years. The De Groot staging system was used to classify WDTC in a total of 320 patients (240 females and 80 males). Among the subjects, the pathological subtypes identified were as follows: Papillary carcinoma (240 cases, 75%), follicular carcinoma (67 cases, 21%) and Hürthle cell carcinoma (13 cases, 4%). Prognostic factors that significantly affected the clinical outcome of the disease were advanced age (P=0.001), tumor size (P=0.03), presence of thyroglobulin (P=0.001) and De Groot stage (P=0.005). The 10‑year follow‑up study revealed that WDTC is associated with a high survival rate of 96% (307/320 patients survived) and a low mortality rate (4%).
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
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Spandidos Publications style
Lei S, Ding Z, Ge J and Zhao D: Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study. Oncol Lett 10: 1749-1754, 2015.
APA
Lei, S., Ding, Z., Ge, J., & Zhao, D. (2015). Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study. Oncology Letters, 10, 1749-1754. https://doi.org/10.3892/ol.2015.3416
MLA
Lei, S., Ding, Z., Ge, J., Zhao, D."Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study". Oncology Letters 10.3 (2015): 1749-1754.
Chicago
Lei, S., Ding, Z., Ge, J., Zhao, D."Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study". Oncology Letters 10, no. 3 (2015): 1749-1754. https://doi.org/10.3892/ol.2015.3416