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Article

Expression of p16 protein in infantile hemangioma

  • Authors:
    • Shi Wang
    • Wei Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, The Third Central Hospital, Tianjin 300170, P.R. China, Department of Orthodontics, Tianjin Stomatological Hospital, Nankai University, Tianjin 300041, P.R. China
  • Pages: 1589-1592
    |
    Published online on: June 24, 2015
       https://doi.org/10.3892/ol.2015.3418
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Abstract

The present study aimed to investigate the expression and significance of p16 in the occurrence, development and regression of infantile hemangioma (IH). The expression of p16 was examined in proliferating, involuting hemangioma and normal tissues using immunohistochemical techniques. The expression of p16 was significantly lower in proliferating hemangioma than in involuting hemangioma, and was significantly lower in the involuting hemangioma than in normal tissues. Significant differences were found between the three groups (P<0.05). The results indicate that p16 may be important in the regression of IH endothelial cells and in anti‑angiogenesis. There is a certain association between p16 expression and the regression of hemangioma. This provides a theoretical basis for the further study of the pathological mechanisms of p16 in hemangioma and potential gene therapies that may treat this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Wang S and Zheng W: Expression of p16 protein in infantile hemangioma. Oncol Lett 10: 1589-1592, 2015.
APA
Wang, S., & Zheng, W. (2015). Expression of p16 protein in infantile hemangioma. Oncology Letters, 10, 1589-1592. https://doi.org/10.3892/ol.2015.3418
MLA
Wang, S., Zheng, W."Expression of p16 protein in infantile hemangioma". Oncology Letters 10.3 (2015): 1589-1592.
Chicago
Wang, S., Zheng, W."Expression of p16 protein in infantile hemangioma". Oncology Letters 10, no. 3 (2015): 1589-1592. https://doi.org/10.3892/ol.2015.3418
Copy and paste a formatted citation
x
Spandidos Publications style
Wang S and Zheng W: Expression of p16 protein in infantile hemangioma. Oncol Lett 10: 1589-1592, 2015.
APA
Wang, S., & Zheng, W. (2015). Expression of p16 protein in infantile hemangioma. Oncology Letters, 10, 1589-1592. https://doi.org/10.3892/ol.2015.3418
MLA
Wang, S., Zheng, W."Expression of p16 protein in infantile hemangioma". Oncology Letters 10.3 (2015): 1589-1592.
Chicago
Wang, S., Zheng, W."Expression of p16 protein in infantile hemangioma". Oncology Letters 10, no. 3 (2015): 1589-1592. https://doi.org/10.3892/ol.2015.3418
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