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September-2015 Volume 10 Issue 3

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

T-box 2 expression predicts poor prognosis in gastric cancer

  • Authors:
    • Haihua Yu
    • Bo Liu
    • Aiwu Liu
    • Kai Li
    • Hongpeng Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China
  • Pages: 1689-1693
    |
    Published online on: June 26, 2015
       https://doi.org/10.3892/ol.2015.3428
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Abstract

T-Box 2 (TBX2) plays a critical role in embryonic development. Previously, TBX2 has been suggested to be involved in malignancies. However, the role of TBX2 in gastric cancer (GC) remains unclear. In the present study, TBX2 expression was found to be evidently upregulated in GC compared with the expression in the corresponding adjacent non‑cancerous tissues at the mRNA and protein levels. Using immunohistochemical analysis on the tissue samples obtained from 266 patients with GC, TBX2 expression was found to be significantly associated with the clinical stage and incidence of vascular invasion and metastasis. Patients with GC that expressed TBX2 demonstrated a shorter overall survival time compared with the patients without TBX2 expression. Multivariate analysis revealed that TBX2 expression was an independent prognostic factor for overall survival (hazard ratio, 3.930; 95% confidence interval, 2.041‑7.917; P=0.009). These results indicated that TBX2 is a prognostic marker for patients with GC.
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Copy and paste a formatted citation
Spandidos Publications style
Yu H, Liu B, Liu A, Li K and Zhao H: T-box 2 expression predicts poor prognosis in gastric cancer. Oncol Lett 10: 1689-1693, 2015.
APA
Yu, H., Liu, B., Liu, A., Li, K., & Zhao, H. (2015). T-box 2 expression predicts poor prognosis in gastric cancer. Oncology Letters, 10, 1689-1693. https://doi.org/10.3892/ol.2015.3428
MLA
Yu, H., Liu, B., Liu, A., Li, K., Zhao, H."T-box 2 expression predicts poor prognosis in gastric cancer". Oncology Letters 10.3 (2015): 1689-1693.
Chicago
Yu, H., Liu, B., Liu, A., Li, K., Zhao, H."T-box 2 expression predicts poor prognosis in gastric cancer". Oncology Letters 10, no. 3 (2015): 1689-1693. https://doi.org/10.3892/ol.2015.3428
Copy and paste a formatted citation
x
Spandidos Publications style
Yu H, Liu B, Liu A, Li K and Zhao H: T-box 2 expression predicts poor prognosis in gastric cancer. Oncol Lett 10: 1689-1693, 2015.
APA
Yu, H., Liu, B., Liu, A., Li, K., & Zhao, H. (2015). T-box 2 expression predicts poor prognosis in gastric cancer. Oncology Letters, 10, 1689-1693. https://doi.org/10.3892/ol.2015.3428
MLA
Yu, H., Liu, B., Liu, A., Li, K., Zhao, H."T-box 2 expression predicts poor prognosis in gastric cancer". Oncology Letters 10.3 (2015): 1689-1693.
Chicago
Yu, H., Liu, B., Liu, A., Li, K., Zhao, H."T-box 2 expression predicts poor prognosis in gastric cancer". Oncology Letters 10, no. 3 (2015): 1689-1693. https://doi.org/10.3892/ol.2015.3428
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