Acute monocytic leukaemia with t(11; 12) (p15; q13) chromosomal changes: A case report and literature review

  • Authors:
    • Jiasheng Hu
    • Xiuli Hong
    • Zhe Li
    • Quanyi Lu
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  • Published online on: July 20, 2015     https://doi.org/10.3892/ol.2015.3511
  • Pages: 2307-2310
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Abstract

Acute myeloid leukaemia (AML) is a type of heterogeneous disease derived from haematopoietic stem cells. Cytogenetic characterisation is essential for diagnosis and prognosis stratification. Here, we present the case of a 43‑year‑old female diagnosed with leukaemia, who demonstrated a rare chromosomal change of t(11; 12) (p15; q13) along with a positive FLT3‑ITD mutation. The patient had a white blood cell count of 76.41x109/l. Bone marrow morphology revealed that monoblasts accounted for 25.5% of cells, and premonocytes accounted for 49.0%. This patient strongly responded to idarubicin and Ara‑c (cytarabine) chemotherapy, which rapidly eliminated the leukaemia cell clones. However, the proliferation rate of the leukaemia cells was high during the intermission of chemotherapy. Subsequently, following two courses of chemotherapy, full haematological remission could not be attained. AML patients with t(11; 12) (p15; q13) combined with FLT3‑ITD mutations are expected to have a short life expectancy; however, early haematopoietic stem cell transplantation therapy may improve the treatment outcome for these patients.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hu J, Hong X, Li Z and Lu Q: Acute monocytic leukaemia with t(11; 12) (p15; q13) chromosomal changes: A case report and literature review. Oncol Lett 10: 2307-2310, 2015.
APA
Hu, J., Hong, X., Li, Z., & Lu, Q. (2015). Acute monocytic leukaemia with t(11; 12) (p15; q13) chromosomal changes: A case report and literature review. Oncology Letters, 10, 2307-2310. https://doi.org/10.3892/ol.2015.3511
MLA
Hu, J., Hong, X., Li, Z., Lu, Q."Acute monocytic leukaemia with t(11; 12) (p15; q13) chromosomal changes: A case report and literature review". Oncology Letters 10.4 (2015): 2307-2310.
Chicago
Hu, J., Hong, X., Li, Z., Lu, Q."Acute monocytic leukaemia with t(11; 12) (p15; q13) chromosomal changes: A case report and literature review". Oncology Letters 10, no. 4 (2015): 2307-2310. https://doi.org/10.3892/ol.2015.3511