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Overexpression of long non‑coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia

  • Authors:
    • Shenghao Wu
    • Cuiping Zheng
    • Songyan Chen
    • Xiaoping Cai
    • Yuejian Shi
    • Bijing Lin
    • Yuemiao Chen

  • View Affiliations

  • Published online on: July 30, 2015     https://doi.org/10.3892/ol.2015.3552
  • Pages: 2410-2414
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Abstract

The long non‑coding RNA, HOX transcript antisense intergenic RNA (HOTAIR), has been indicated to have involvement in a number of cancers, however, its role in acute myeloid leukemia (AML) is unknown. The present study aimed to investigate the pattern of HOTAIR expression in AML and to evaluate its clinical significance in tumor progression. Quantitative polymerase chain reaction was performed to examine the HOTAIR expression in mononuclear cells from the bone marrow (BM) or peripheral blood specimens of 85 patients with newly diagnosed AML. The association of HOTAIR expression with the clinicopathological factors and prognosis of AML patients was statistically analyzed. The expression of HOTAIR was significantly upregulated in the AML patients compared with the healthy controls (mean expression value, 3.87±0.29 vs. 1.28±0.09; P<0.001), and markedly decreased in the patients post‑treatment compared with pre‑treatment (4.76±0.47 vs. 2.81±0.27; P<0.001). Moreover, high levels of HOTAIR were associated with higher white blood cell and BM blast counts (P<0.001 and P=0.001, respectively), and lower hemoglobin and platelet counts (P=0.007 and 0.001, respectively). Patients with a high level of HOTAIR expression had relatively poor overall survival (OS; 20.5 vs. 32.1 months, P=0.001) and relapse‑free survival (21.5 vs. 33.6 months, P=0.001) times compared with those with a low level of HOTAIR expression. These data demonstrated that HOTAIR expression was upregulated in newly diagnosed AML patients and was associated with leukemic burden, and DFS and OS times. HOTAIR may represent a biomarker of a poor prognosis and is a potential therapeutic target for AML treatment.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • Source Normalized Impact per Paper (SNIP): 0.574
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Spandidos Publications style
Wu S, Zheng C, Chen S, Cai X, Shi Y, Lin B and Chen Y: Overexpression of long non‑coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia. Oncol Lett 10: 2410-2414, 2015.
APA
Wu, S., Zheng, C., Chen, S., Cai, X., Shi, Y., Lin, B., & Chen, Y. (2015). Overexpression of long non‑coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia. Oncology Letters, 10, 2410-2414. https://doi.org/10.3892/ol.2015.3552
MLA
Wu, S., Zheng, C., Chen, S., Cai, X., Shi, Y., Lin, B., Chen, Y."Overexpression of long non‑coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia". Oncology Letters 10.4 (2015): 2410-2414.
Chicago
Wu, S., Zheng, C., Chen, S., Cai, X., Shi, Y., Lin, B., Chen, Y."Overexpression of long non‑coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia". Oncology Letters 10, no. 4 (2015): 2410-2414. https://doi.org/10.3892/ol.2015.3552