Prognostic impact of progesterone receptor status combined with body mass index in breast cancer patients treated with adjuvant aromatase inhibitor

  • Authors:
    • Masahiro Ohara
    • Etsushi Akimoto
    • Midori Noma
    • Kazuo Matsuura
    • Mihoko Doi
    • Naoki Kagawa
    • Toshiyuki Itamoto
  • View Affiliations

  • Published online on: August 28, 2015     https://doi.org/10.3892/ol.2015.3655
  • Pages: 3286-3292
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Abstract

Aromatase inhibitors have played a central role in endocrine therapy for the treatment of estrogen receptor (ER)‑positive breast cancer in postmenopausal patients. However, prognostic factors for recurrence following such treatment have not been identified. The current study aimed to validate the prognostic value of endocrine‑related progesterone receptor (PgR) status combined with body mass index (BMI). Among 659 consecutive patients with primary breast cancer who underwent curative surgery between 2002 and 2012, 184 postmenopausal patients with ER‑positive (ER+) and human epidermal growth factor receptor type 2‑negative (HER2‑) breast cancer who were treated with adjuvant aromatase inhibitor therapy were assessed. The patients were assigned to groups based on BMI, according to the WHO cut‑off value: ≥25 kg/m2 (high, H) or <25 kg/m2 (low, L). Positive nodal status, negative PgR status, BMI‑H and a high Ki-67 labeling index (≥20%) were found to be significantly associated with a short recurrence‑free interval (RFI) upon univariate analysis (P=0.048, 0.007, 0.027, and 0.012, respectively). The patients were further grouped based on their combined PgR/BMI status. The RFI was significantly shorter in the PgR‑ and/or BMI‑H group compared with that of the PgR+/BMI‑L group (P=0.012). Multivariate analysis revealed PgR‑ tumors and/or BMI‑H and positive nodal status to be independent prognostic factors (P=0.012 and 0.020, respectively). The present findings indicate that PgR/BMI status may serve as a practical tool in the management of ER+ and HER2‑ breast cancer in patients treated with adjuvant aromatase inhibitors.
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November-2015
Volume 10 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ohara M, Akimoto E, Noma M, Matsuura K, Doi M, Kagawa N and Itamoto T: Prognostic impact of progesterone receptor status combined with body mass index in breast cancer patients treated with adjuvant aromatase inhibitor. Oncol Lett 10: 3286-3292, 2015.
APA
Ohara, M., Akimoto, E., Noma, M., Matsuura, K., Doi, M., Kagawa, N., & Itamoto, T. (2015). Prognostic impact of progesterone receptor status combined with body mass index in breast cancer patients treated with adjuvant aromatase inhibitor. Oncology Letters, 10, 3286-3292. https://doi.org/10.3892/ol.2015.3655
MLA
Ohara, M., Akimoto, E., Noma, M., Matsuura, K., Doi, M., Kagawa, N., Itamoto, T."Prognostic impact of progesterone receptor status combined with body mass index in breast cancer patients treated with adjuvant aromatase inhibitor". Oncology Letters 10.5 (2015): 3286-3292.
Chicago
Ohara, M., Akimoto, E., Noma, M., Matsuura, K., Doi, M., Kagawa, N., Itamoto, T."Prognostic impact of progesterone receptor status combined with body mass index in breast cancer patients treated with adjuvant aromatase inhibitor". Oncology Letters 10, no. 5 (2015): 3286-3292. https://doi.org/10.3892/ol.2015.3655