Primary cardiac malignant fibrous histiocytoma with vulvar metastases: A case report

Sun,Junjie; Liu,Ruihua; Wang,Weiwei; Sun,Minghui; Wang,Lihong; Wang,Xiaofei; Shi,Lei

doi:10.3892/ol.2015.3683

Primary cardiac malignant fibrous histiocytoma with vulvar metastases: A case report

Authors:
- Junjie Sun
- Ruihua Liu
- Weiwei Wang
- Minghui Sun
- Lihong Wang
- Xiaofei Wang
- Lei Shi
View Affiliations

Affiliations: Department of Ultrasound, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China
Published online on: September 8, 2015 https://doi.org/10.3892/ol.2015.3683
Pages: 3153-3156

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Malignant fibrous histiocytoma (MFH) occurring in the heart is rare. To the best of our knowledge, the current study was the first to report a case of left atrial MFH metastasizing to the vulva. A 37‑year‑old female presenting with a history of exertional dyspnea underwent echocardiography, which revealed a mass in the left atrium, with a short‑wide stalk attached to the posterior wall, extending into the pericardium. Furthermore, the mass resulted in severe mitral stenosis during diastole. The tumor was excised together with a section of the left atrial wall. The initial diagnosis was a left atrial myxoma. However, post‑operative frozen section histopathology results indicated a diagnosis of MFH. Following surgery, the patient received chemotherapy, however, vulvar metastases and left pleural effusions were identified after 1 month. Following surgical excision of the vulvar tumor and left thoracentesis, the patient began adjuvant chemotherapy. However, the patient succumbed due to local recurrence 6 months later.

View Figures

View References

1	Straus R and Merliss R: Primary tumor of the heart. Arch Pathol. 39:74–78. 1945.
2	Neragi-Miandoab S, Kim J and Vlahakes GJ: Malignant tumours of the heart: A review of tumour type, diagnosis and therapy. Clin Oncol (R Coll Radiol). 19:748–756. 2007. View Article : Google Scholar : PubMed/NCBI
3	Burke AP, Cowan D and Virmani R: Primary sarcomas of the heart. Cancer. 69:387–395. 1992. View Article : Google Scholar : PubMed/NCBI
4	Stevens CW, Sears-Rogan P, Bitterman P and Torrisi J: Treatment of malignant fibrous histiocytoma of the heart. Cancer. 69:956–961. 1992. View Article : Google Scholar : PubMed/NCBI
5	Okby NT and Travis WD: Liposarcoma of the pleural cavity: Clinical and pathologic features of 4 cases with a review of the literature. Arch Pathol Lab Med. 124:699–703. 2000.PubMed/NCBI
6	Grebenc ML, de Christenson ML Rosado, Burke AP, et al: Primary cardiac and pericardial neoplasms: Radiologic-pathologic correlation. Radiographics. 20:1073–1103. 2000. View Article : Google Scholar : PubMed/NCBI
7	Levine RA, Weyman AE, Dinsmore RE, et al: Noninvasive tissue characterization: Diagnosis of lipomatous hypertrophy of the atrial septum by nuclear magnetic resonance imaging. J Am Coll Cardiol. 7:688–692. 1986. View Article : Google Scholar : PubMed/NCBI
8	Fletcher CD, Gustafson P, Rydholm A, Willén H and Akerman M: Clinicopathologic re-evaluation of 100 malignant fibrous histiocytomas: Prognostic relevance of subclassification. J Clin Oncol. 19:3045–3050. 2001.PubMed/NCBI
9	Burke A, Jeudy J Jr, Virmani R, Topol EJ and Califf RM: Cardiac tumours. Textbook of Cardiovascular Medicine (3rd). Lippincott Williams & Wilkins. (Philadelphia). 7102007.
10	Odim J, Reehal V, Laks H, et al: Surgical pathology of cardiac tumors. Two decades at an urban institution. Cardiovasc Pathol. 12:267–270. 2003. View Article : Google Scholar : PubMed/NCBI
11	Oh SJ, Yeom SY and Kim KH: Clinical implication of surgical resection for the rare cardiac tumors involving heart and great vessels. J Korean Med Sci. 28:717–724. 2013. View Article : Google Scholar : PubMed/NCBI
12	Bakaeen FG, Reardon MJ, Coselli JS, Miller CC, Howell JF, Lawrie GM, Espada R, Ramchandani MK, Noon GP, Weilbaecher DG and DeBakey ME: Surgical outcome in 85 patients with primary cardiac tumors. Am J Surg. 186:641–647. 2003. View Article : Google Scholar : PubMed/NCBI
13	McAllister H and Fenoglio J: Tumors of the cardiovascular system. Atlas of Tumor Pathology (2nd Series). Fascicle 15 American Registry of Pathology/Armed Forces Institute of Pathology. (Washington, D.C.). 1–3. 1978.
14	Yu K, Liu Y, Wang H, Hu S and Long C: Epidemiological and pathological characteristics of cardiac tumors: A clinical study of 242 cases. Interact Cardiovasc Thorac Surg. 6:636–639. 2007. View Article : Google Scholar : PubMed/NCBI
15	Hsieh SC, Chen CY and Chan WP: Malignant fibrous histiocytoma of the heart: A case report. Acta Cardiol. 65:85–87. 2010. View Article : Google Scholar : PubMed/NCBI
16	Sheikh AA, Ahmad M, Lone AR and Banday MA: Cardiac metastasis in malignant fibrous histiocytoma. Saudi Med J. 29:1041–1043. 2008.PubMed/NCBI
17	Milicic D, Juretic A, Bulum J, Saric N, Bisof V, Jelic I and Jelasic D: Primary malignant fibrous histiocytoma of the heart with skeletal muscles metastases. J Card Surg. 22:513–516. 2007. View Article : Google Scholar : PubMed/NCBI
18	Pimentel J, Fernandes AC, Silva R, Ferro J and Cattoni B: Brain metastases of a malignant fibrous histiocytoma presenting as an acute cerebral hemorrhage. Clin Neuropathol. 20:64–69. 2001.PubMed/NCBI
19	Grisaru D, Peyser MR, Bernstein-Lipschitz L, Yaron Y and Lessing JB: Malignant fibrous histiocytoma with myofibroblastic differentiation of the vulva in an adolescent female. Eur J Obstet Gynecol Reprod Biol. 79:219–221. 1998. View Article : Google Scholar : PubMed/NCBI
20	Taylor RN, Bottles K, Miller TR and Braga CA: Malignant fibrous histiocytoma of the vulva. Obstet Gynecol. 66:145–148. 1985.PubMed/NCBI
21	Iwakawa T, Tsuji T, Hamada T, Kamio M, Matsuo T, Yoshinaga M, Kitajima S and Douchi T: Pleomorphic type of malignant fibrous histiocytoma with myxoid stroma of the vulva in a young woman. J Obstet Gynaecol Res. 37:1474–1477. 2011. View Article : Google Scholar : PubMed/NCBI
22	Park BJ, Bacchetta M, Bains MS, Downey RJ, Flores R, Rusch VW and Girardi LN: Surgical management of thoracic malignancies invading the heart or great vessels. Ann Thorac Surg. 78:1024–1030. 2004. View Article : Google Scholar : PubMed/NCBI
23	Eckstein R, Gössner W and Rienmüller R: Primary malignant fibrous histiocytoma of the left atrium. Surgical and chemotherapeutic management. Br Heart J. 52:354–357. 1984. View Article : Google Scholar : PubMed/NCBI
24	Kim MP, Correa AM, Blackmon S, Quiroga-Garza G, Weilbaecher D, Bruckner B, Ramlawi B, Rice DC, Vaporciyan AA and Reardon MJ: Outcomes after right-side heart sarcoma resection. Ann Thorac Surg. 91:770–776. 2011. View Article : Google Scholar : PubMed/NCBI
25	Reardon MJ, Walkes JC and Benjamin R: Therapy insight: Malignant primary cardiac tumors. Nat Clin Pract Cardiovasc Med. 3:548–553. 2006. View Article : Google Scholar : PubMed/NCBI