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Xp11.2 translocation renal cell carcinoma with egg-shell calcification mimicking a benign renal tumour: A case report

  • Authors:
    • Wenjie Liang
    • Shunliang Xu

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  • Published online on: September 17, 2015     https://doi.org/10.3892/ol.2015.3718
  • Pages: 3191-3194
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Abstract

The present study reports the case of a 20-year-old female who was identified to have a left renal angiomyolipoma (AML) with hemorrhage. Following temporary conservative observation, the patient received continuous ultrasonic follow‑up. Due to the rapid growth of the lesion, further examinations were performed. Computed tomography (CT) plain scans revealed a partly high‑density mass with marginal egg‑shell calcification. Enhanced CT revealed a solid tumor with a rich blood supply. Since no fats were detected, the possibility of a typical AML was excluded, but the diagnoses of epithelioid AML or renal cancer were considered. Finally, the left kidney was partially excised laparoscopically. The intraoperative frozen section indicated a diagnosis of renal cell carcinoma (RCC). The left kidney was subsequently radically excised. . Routine histopathological and immunohistochemical tests confirmed that the lesion was an RCC with an Xp11.2 translocation. The present study introduces the pitfalls in the diagnosis of Xp11.2 translocation RCC, which is a rare RCC subtype accompanied with uncommon imaging manifestations. The study suggests that when a rapidly‑growing AML is detected by ultrasound, renal cancer with marginal calcification should be considered. Moreover, although egg‑shell calcification mostly occurs in benign renal lesions, further examinations, such as enhanced CT, are recommended for identifying the nature of the masses and excluding the possibility of malignant tumors.
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November-2015
Volume 10 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • Journal Metrics
  • Impact Factor: 2.5
  • Ranked Oncology
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  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
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Spandidos Publications style
Liang W and Xu S: Xp11.2 translocation renal cell carcinoma with egg-shell calcification mimicking a benign renal tumour: A case report. Oncol Lett 10: 3191-3194, 2015.
APA
Liang, W., & Xu, S. (2015). Xp11.2 translocation renal cell carcinoma with egg-shell calcification mimicking a benign renal tumour: A case report. Oncology Letters, 10, 3191-3194. https://doi.org/10.3892/ol.2015.3718
MLA
Liang, W., Xu, S."Xp11.2 translocation renal cell carcinoma with egg-shell calcification mimicking a benign renal tumour: A case report". Oncology Letters 10.5 (2015): 3191-3194.
Chicago
Liang, W., Xu, S."Xp11.2 translocation renal cell carcinoma with egg-shell calcification mimicking a benign renal tumour: A case report". Oncology Letters 10, no. 5 (2015): 3191-3194. https://doi.org/10.3892/ol.2015.3718