2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis

  • Authors:
    • Yuqing Sheng
    • Mingchang Zou
    • Yan Wang
    • Qiheng Li
  • View Affiliations

  • Published online on: October 12, 2015     https://doi.org/10.3892/ol.2015.3795
  • Pages: 3737-3741
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Abstract

Natural products are a promising source for the development of novel cancer therapies, due to their potential effectiveness and low toxicity profiles. As a main component of Herba oxytropis, 2',4'‑dihydroxychalcone (TFC) is known to demonstrate anti‑tumor activity in vitro. In the present study, TFC was found to potently inhibit proliferation and induce apoptosis in PC‑3 human prostate cancer cells in a dose‑dependent manner. The results demonstrated that the induction of apoptosis is associated with cell cycle arrest at the G0/G1 phase and activation of caspase‑3/‑7. Additional mechanistic studies of two biomarkers, phosphatase and tensin homolog (PTEN) and cyclin‑dependent kinase inhibitor 1B (p27Kip1), in prostate cancer revealed that TFC treatment significantly upregulated the expression of PTEN and p27Kip1. The findings of the present study indicate that TFC‑induced apoptosis in PC‑3 cells via upregulation of PTEN and p27Kip1, which results in cell cycle arrest in G0/G1 phase, activation of caspase‑3/‑7 and induction of apoptosis. Therefore, TFC may be a potential compound for human prostate cancer therapy.
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December-2015
Volume 10 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Sheng Y, Zou M, Wang Y and Li Q: 2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis. Oncol Lett 10: 3737-3741, 2015.
APA
Sheng, Y., Zou, M., Wang, Y., & Li, Q. (2015). 2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis. Oncology Letters, 10, 3737-3741. https://doi.org/10.3892/ol.2015.3795
MLA
Sheng, Y., Zou, M., Wang, Y., Li, Q."2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis". Oncology Letters 10.6 (2015): 3737-3741.
Chicago
Sheng, Y., Zou, M., Wang, Y., Li, Q."2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis". Oncology Letters 10, no. 6 (2015): 3737-3741. https://doi.org/10.3892/ol.2015.3795