Intracranial solitary fibrous tumors: A report of two cases and a review of the literature

Wang,Zi‑Yan; Qiu,Kai; Ma,Yi‑Hui; Wang,Xiao‑Tao; Bao,Jian‑Ji; Zhang,Zhi‑Feng; Liu,Xian‑Zhi

doi:10.3892/ol.2015.3985

Intracranial solitary fibrous tumors: A report of two cases and a review of the literature

Authors:
- Zi‑Yan Wang
- Kai Qiu
- Yi‑Hui Ma
- Xiao‑Tao Wang
- Jian‑Ji Bao
- Zhi‑Feng Zhang
- Xian‑Zhi Liu
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Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Published online on: December 2, 2015 https://doi.org/10.3892/ol.2015.3985
Pages: 1057-1060

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Abstract

Solitary fibrous tumors (SFTs) are uncommon, with the pleura as a site of predilection. Central nervous system SFTs, particularly intracranial SFTs, are extremely rare. The lesions are generally benign and localized, and surgery is the main therapeutic solution. The current study reports the cases of a patient who presented with right haunch pain, right leg weakness and paresthesias for several months, and a patient with a history of unexpected loss of consciousness. Magnetic resonance imaging revealed the presence of lesions, with a spindle cell morphology evident on pathological examination. The immunohistochemical examination demonstrated a strong immunoreaction for cluster of differentiation 34, which supported the diagnosis of an SFT. Following a near-total resection, the patients had a good neural prognosis. The present study also provides a literature review, discussing the imageological and pathological characteristics of SFT, and the diagnostic methods that aid in distinguishing the entity from other spindle-cell central nervous system tumors.

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1	Suzuki SO, Fukui M, Nishio S and Iwaki T: Clinicopathological features of solitary fibrous tumor of the meninges, An immunohistochemical reappraisal of cases previously diagnosed to be fibrous meningioma or hemangiopericytoma. Pathol Int. 50:808–817. 2000. View Article : Google Scholar : PubMed/NCBI
2	Carneiro SS, Scheithauer BW, Nascimento AG, Hirose T and Davis DH: Solitary fibrous tumor of the meninges, A lesion distinct from fibrous meningioma. Histopathology. Am J Clin Pathol. 106:217–224. 1996.PubMed/NCBI
3	Suster S, Nascimento AG, Miettinen M, Sickel JZ and Moran CA: Solitary fibrous tumors of soft tissue. Histopathology. Am J Surg Pathol. 19:1257–1266. 1995. View Article : Google Scholar : PubMed/NCBI
4	Gold JS, Antonescu CR, Hajdu C, Ferrone CR, Hussain M, Lewis JJ, Brennan MF and Coit DG: Clinicopathologic correlates of solitary fibrous tumors. Cancer. 94:1057–1068. 2002. View Article : Google Scholar : PubMed/NCBI
5	Klemperer P and Rabin CB: Primary neoplasia of the pleura: A report of five cases. Arch Pathol. 1:385–412. 1931.
6	Brunori A, Cerasoli S, Donati R, Giangaspero F and Chiappetta F: Solitary fibrous tumor of the meninges, Two new cases and review of the literature. Surg Neurol. 51:636–640. 1999. View Article : Google Scholar : PubMed/NCBI
7	Fargen KM, Opalach KJ, Wakefield D, Jacob RP, Yachnis AT and Lister JR: The central nervous system solitary fibrous tumor, A review of clinical, imaging and pathologic findings among all reported cases from 1996 to 2010. Clin Neurol Neurosurg. 113:703–710. 2011. View Article : Google Scholar : PubMed/NCBI
8	Fina L, Molgaard HV, Robertson D, Bradley NJ, Monaghan P, Delia D, Sutherland DR, Baker MA and Greaves MF: Expression of the CD34 gene in vascular endothelial cells. Blood. 75:2417–2426. 1990.PubMed/NCBI
9	Ng HK, Choi PC, Wong CW, To KF and Poon WS: Metastatic solitary fibrous tumor of the meninges. Histopathology. J Neurosurg. 93:490–493. 2000. View Article : Google Scholar : PubMed/NCBI
10	Alawi F, Stratton D and Freedman PD: Solitary fibrous tumor of the oral soft tissues, A clinicopathologic and immunohistochemical study of 16 cases. Am J Surg Pathol. 25:900–910. 2001. View Article : Google Scholar : PubMed/NCBI
11	Chen HJ, Zhang HY, Li X, Guo LX, Wei B, Guo H, Bu H, Yang K and Liu BL: Solitary fibrous tumor, The clinicopathologic and immunohistochemical characteristics of 26 cases. Sichuan Da Xue Xue Bao Yi Xue Ban. 35:675–679. 2004.(In Chinese). PubMed/NCBI
12	Zhang H, Lucas DR, Pass HI and Che M: Disseminated malignant solitary fibrous tumor of the pleura. Pathol Int. 54:111–115. 2004. View Article : Google Scholar : PubMed/NCBI
13	Artlich A and Schmidt D: Immunohistochemical profile of meningiomas and their histological subtypes. Hum Pathol. 21:843–849. 1990. View Article : Google Scholar : PubMed/NCBI
14	Das A, Tan WL and Smith DR: Expression of extracellular matrix markers in benign meningiomas. Neuropathology. 23:275–281. 2003. View Article : Google Scholar : PubMed/NCBI
15	Kobayashi K, Imagama S, Ito Z, Ando K, Ukai J, Muramoto A, Shinjo R, Matsumoto T, Nakashima H, Matsuyama Y and Ishiguro N: Recurrence of solitary fibrous tumor of the cervical spinal cord. Nagoya J Med Sci. 76:217–223. 2014.PubMed/NCBI
16	Ishii K, Nakamura M, Matsumoto M, Mukai M, Toyama Y and Chiba K: Intramedullary solitary fibrous tumor of the spinal cord. J Orthop Sci. 14:450–454. 2009. View Article : Google Scholar : PubMed/NCBI
17	Munks S: Solitary fibrous tumor (SFT) of the nasal mucosa. Laryngorhinootologie. 82:655–658. 2003.(In German). View Article : Google Scholar : PubMed/NCBI
18	Ambrosini-Spaltro A and Eusebi V: Meningeal hemangiopericytomas and hemangiopericytoma/solitary fibrous tumors of extracranial soft tissues: A comparison. Virchows Arch. 456:343–354. 2010. View Article : Google Scholar : PubMed/NCBI
19	Perry A, Scheithauer BW and Nascimento AG: The immunophenotypic spectrum of meningeal hemangiopericytoma, A comparison with fibrous meningioma and solitary fibrous tumor of meninges. Am J Surg Pathol. 21:1354–1360. 1997. View Article : Google Scholar : PubMed/NCBI
20	Nielsen GP, O'Connell JX, Dickersin GR and Rosenberg AE: Solitary fibrous tumor of soft tissue, A report of 15 cases, including 5 malignant examples with light microscopic, immunohistochemical and ultrastructural data. Mod Pathol. 10:1028–1037. 1997.PubMed/NCBI
21	Suzuki SO, Fukui M, Nishio S and Iwaki T: Clinicopathological features of solitary fibrous tumor of the meninges, An immunohistochemical reappraisal of cases previously diagnosed to be fibrous meningioma or hemangiopericytoma. Pathol Int. 50:808–817. 2000. View Article : Google Scholar : PubMed/NCBI
22	Prayson RA, McMahon JT and Barnett GH: Solitary fibrous tumor of the meninges. Histopathology. J Neurosurg. 86:1049–1052. 1997. View Article : Google Scholar : PubMed/NCBI
23	Koçak A, Cayli SR, Saraç K and Aydin NE: Intraventricular solitary fibrous tumor: An unusual tumor with radiological, ultrastructural and immunohistochemical evaluation, Case report. Neurosurgery. 54:213–216; discussion 216–217. 2004. View Article : Google Scholar
24	Caroli E, Salvati M, Orlando ER, Lenzi J, Santoro A and Giangaspero F: Solitary fibrous tumors of the meninges, Report of four cases and literature review. Neurosurg Rev. 27:246–251. 2004. View Article : Google Scholar : PubMed/NCBI
25	Ahn JY, Shim JY, Yang WI and Kim TS: Meningeal solitary fibrous tumor as an unusual cause of exophthalmos, Case report and review of the literature. Neurosurgery. 48:1362–1366. 2001. View Article : Google Scholar : PubMed/NCBI
26	Gidwani AL, Mullan FJ and Kenny B: Solitary fibrous tumour of the falciform ligament containing multiple foci of malignant transformation. J Clin Pathol. 57:546–547. 2004. View Article : Google Scholar : PubMed/NCBI