Correlation of FOXC1 protein with clinicopathological features in serous ovarian tumors

Wang,Lu‑Ying; Li,Lan‑Shuang; Yang,Zhu

doi:10.3892/ol.2015.3996

Correlation of FOXC1 protein with clinicopathological features in serous ovarian tumors

Authors:
- Lu‑Ying Wang
- Lan‑Shuang Li
- Zhu Yang
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Affiliations: Department of Gynecology and Obstetrics, Chengdu Women and Children's Hospital, Chengdu, Sichuan 610091, P.R. China, Department of Gynecology and Obstetrics, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China
Published online on: December 3, 2015 https://doi.org/10.3892/ol.2015.3996
Pages: 933-938
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Transcriptional factor FOXC1 has been demonstrated to play a key role in embryogenesis in animal studies and may participate in tumorigenesis. However, the specific function of this gene in ovarian tumors has not been fully determined. In this study, potential correlations between FOXC1 expression and clinicopathological features of serous ovarian tumors were investigated. FOXC1 expression was analyzed in SKOV‑3 and HO‑8910 cell lines and serous ovarian tumor tissues. A significant correlation was observed between FOXC1 protein expression and pathological subtype as well as FIGO stage (P<0.05) in serous ovarian tumors in our retrospective study. No significant association was revealed between FOXC1 protein expression and the clinicopathological factors of age, histological grade and volume of ascites (P>0.05). The results suggest that high expression of FOXC1 protein may serve as a marker for benign serous ovarian tumors and a suggest a trend towards good prognosis.

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