Primary gastric natural killer/T-cell lymphoma with diffuse CD30 expression and without CD56 expression: A case report

Zhang,Lizhi; Zhang,Pengxin; Wen,Jinhui; Chen,Xuehua; Zhang,Hua

doi:10.3892/ol.2015.4015

Primary gastric natural killer/T-cell lymphoma with diffuse CD30 expression and without CD56 expression: A case report

Authors:
- Lizhi Zhang
- Pengxin Zhang
- Jinhui Wen
- Xuehua Chen
- Hua Zhang
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Affiliations: Department of Pathology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Geratology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
Published online on: December 9, 2015 https://doi.org/10.3892/ol.2015.4015
Pages: 969-972
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The majority of natural killer (NK)/T-cell lymphomas occur in the nasal cavity and rarely involve the stomach. They possess a specific immunophenotype, with the expression of cluster of differentiation (CD)56, CD2 and CD3ε, but without CD3 expression. Few cases of NK/T‑cell lymphoma have partial CD30 expression. The present study reveals a unique case of a 41‑year‑old female patient with gastric NK/T‑cell lymphoma that did not express CD56 and diffusely expressed CD30. Immunohistochemical staining demonstrated that the tumor cells expressed CD3ε, CD43, CD30 and granzyme B and did not express CD2, CD4, CD5, CD7, CD8, CD56, anaplastic lymphoma kinase, CD20, paired box‑5 or pan cytokeratin. Based on the immunostaining profile and morphological features, the initial diagnosis considered was gastric anaplastic large cell lymphoma. However, following a consultation with other pathologists, the Epstein‑Barr virus (EBV) status of the patient was investigated to exclude a diagnosis of NK/T‑cell lymphoma. Notably, the signal for EBV RNA was diffuse positive. Therefore, the final diagnosis was corrected to NK/T‑cell lymphoma. To the best of our knowledge, the present study is the first to report NK/T-cell lymphoma in the stomach with a diffuse CD30-positive and CD56-negative phenotype.

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