Imaging findings of malignant bilateral carotid body tumors: A case report and review of the literature

Lv,Han; Chen,Xiaohong; Zhou,Shuai; Cui,Suping; Bai,Yunlong; Wang,Zhenchang

doi:10.3892/ol.2016.4227

Imaging findings of malignant bilateral carotid body tumors: A case report and review of the literature

Authors:
- Han Lv
- Xiaohong Chen
- Shuai Zhou
- Suping Cui
- Yunlong Bai
- Zhenchang Wang
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Affiliations: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China, Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China, Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China, Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China, Department of Otolaryngology, Head and Neck Surgery, Fuxing Hospital, Capital Medical University, Beijing 100038, P.R. China
Published online on: February 15, 2016 https://doi.org/10.3892/ol.2016.4227
Pages: 2457-2462

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Abstract

Carotid body tumors (CBTs) are a rare type of extra-adrenal paraganglioma, which originate from the carotid body. A 29-year-old woman was admitted to the Department of Head and Neck Surgery, Beijing Tongren Hospital (Capital Medical University, Beijing, China) with hoarseness of the throat, which had progressively worsened over seven months. The patient had a family history of CBTs. Computed tomography and ultrasound imaging revealed multiple well‑enhanced masses located at the bilateral carotid bifurcation and in the left parapharyngeal space. Surgery and pathological examination confirmed that the patient had developed regional lymph node metastasis. Significantly enhanced multiple pulmonary and hepatic lesions indicated that the patient had also developed distal metastasis. A genetic analysis performed on the family members of the patient revealed that the family carried a mutated succinate dehydrogenase D gene. In the present study, a systemic review of the literature indicated that extra vigilance is required in familial forms of CBT, in order to increase the standard of treatment for CBT patients.

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1	Andersen KF, Altaf R, Krarup-Hansen A, Kromann-Andersen B, Horn T, Christensen NJ and Hendel HW: Malignant pheochromocytomas and paragangliomas - the importance of a multidisciplinary approach. Cancer Treat Rev. 37:111–119. 2011. View Article : Google Scholar : PubMed/NCBI
2	Lee JH, Barich F, Karnell LH, Robinson RA, Zhen WK, Gantz BJ and Hoffman HT: American College of Surgeons Commission on Cancer; American Cancer Society: National Cancer Data Base report on malignant paragangliomas of the head and neck. Cancer. 94:730–737. 2002. View Article : Google Scholar : PubMed/NCBI
3	Patetsios P, Gable DR, Garrett WV, Lamont JP, Kuhn JA, Shutze WP, Kourlis H, Grimsley B, Pearl GJ, Smith BL, et al: Management of carotid body paragangliomas and review of a 30-year experience. Ann Vasc Surg. 16:331–338. 2002. View Article : Google Scholar : PubMed/NCBI
4	Young AL, Baysal BE, Deb A and Young WF Jr: Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene. J Clin Endocrinol Metab. 87:4101–4105. 2002. View Article : Google Scholar : PubMed/NCBI
5	Hammer S, Jansen JC, van der Kleij-Corssmit EP, Hes FJ and Kruit MC: Case of spontaneous regression of carotid body tumor in a SDHD mutant: A discussion on potential mechanisms based on a review of the literature. World J Surg Oncol. 10:2182012. View Article : Google Scholar : PubMed/NCBI
6	Taylor H: Bilateral carotid body tumour. Proc R Soc Med. 58:173–175. 1965.PubMed/NCBI
7	Sugarbaker EV, Chretien PB and Jacobs JB: Bilateral familial carotid body tumors: Report of a patient with an occult contralateral tumor and postoperative hypertension. Ann Surg. 174:242–247. 1971. View Article : Google Scholar : PubMed/NCBI
8	Lewison EF and Weinberg T: Carotid Body Tumors. A case report of bilateral carotid body tumors with an unusual family incidence. Surgery. 27:4371950.
9	Chase WH: Familial and bilateral tumors of the carotid body. J Path Bact. 36:1–12. 1933. View Article : Google Scholar
10	Wilson H: Carotid body tumors. Familial and bilateral. Ann Surg. 171:843–848. 1970. View Article : Google Scholar : PubMed/NCBI
11	Hall TC, Renwick P and Stafford ND: Recurrent familial malignant carotid body tumour presenting with lymph node metastasis: Case report, and review of diagnosis and management of familial carotid body tumours. J Laryngol Otol. 124:1344–1346. 2010. View Article : Google Scholar : PubMed/NCBI
12	Grufferman S, Gillman MW, Pasternak LR, Peterson CL and Young WG Jr: Familial carotid body tumors: Case report and epidemiologic review. Cancer. 46:2116–2122. 1980. View Article : Google Scholar : PubMed/NCBI
13	Nishijima H, Asakage T and Sugasawa M: Malignant carotid body tumor with systemic metastases. Ann Otol Rhinol Laryngol. 120:381–385. 2011. View Article : Google Scholar : PubMed/NCBI
14	Lack EE, Cubilla AL and Woodruff JM: Paragangliomas of the head and neck region. A pathologic study of tumors from 71 patients. Hum Pathol. 10:191–218. 1979. View Article : Google Scholar : PubMed/NCBI
15	Lau D, La Marca F, Camelo-Piragua S and Park P: Metastatic paraganglioma of the spine: Case report and review of the literature. Clin Neurol Neurosurg. 115:1571–1574. 2013. View Article : Google Scholar : PubMed/NCBI
16	Eisenhofer G, Bornstein SR, Brouwers FM, Cheung NK, Dahia PL, de Krijger RR, Giordano TJ, Greene LA, Goldstein DS, Lehnert H, et al: Malignant pheochromocytoma: Current status and initiatives for future progress. Endocr Relat Cancer. 11:423–436. 2004. View Article : Google Scholar : PubMed/NCBI
17	Goldstein RE, O'Neill JA Jr, Holcomb GW III, Morgan WM III, Neblett WW III, Oates JA, Brown N, Nadeau J, Smith B, Page DL, et al: Clinical experience over 48 years with pheochromocytoma. Ann Surg. 229:755–764. 1999. View Article : Google Scholar : PubMed/NCBI
18	Neumann HP, Pawlu C, Peczkowska M, Bausch B, McWhinney SR, Muresan M, Buchta M, Franke G, Klisch J, Bley TA, et al: European-American Paraganglioma Study Group: Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. JAMA. 292:943–951. 2004. View Article : Google Scholar : PubMed/NCBI
19	Rush BF Jr: Familial bilateral carotid body tumors. Ann Surg. 157:633–636. 1963. View Article : Google Scholar : PubMed/NCBI
20	Havekes B, Corssmit EP, Jansen JC, van der Mey AG, Vriends AH and Romijn JA: Malignant paragangliomas associated with mutations in the succinate dehydrogenase D gene. J Clin Endocrinol Metab. 92:1245–1248. 2007. View Article : Google Scholar : PubMed/NCBI
21	Peck BW, Rich TA, Jimenez C and Kupferman ME: A novel SDHB mutation associated with hereditary head and neck paraganglioma. Laryngoscope. 121:2572–2575. 2011. View Article : Google Scholar : PubMed/NCBI
22	Pacheco-Ojeda LA and Martínez-Viteri MA: Preoperative imaging diagnosis of carotid body tumors. Int Surg. 95:242–246. 2010.PubMed/NCBI
23	Lee KY, Oh YW, Noh HJ, Lee YJ, Yong HS, Kang EY, Kim KA and Lee NJ: Extraadrenal paragangliomas of the body: Imaging features. AJR Am J Roentgenol. 187:492–504. 2006. View Article : Google Scholar : PubMed/NCBI
24	Alkadhi H, Schuknecht B, Stoeckli SJ and Valavanis A: Evaluation of topography and vascularization of cervical paragangliomas by magnetic resonance imaging and color duplex sonography. Neuroradiology. 44:83–90. 2002. View Article : Google Scholar : PubMed/NCBI
25	Fritzsche FR, Bode PK, Koch S and Frauenfelder T: Radiological and pathological findings of a metastatic composite paraganglioma with neuroblastoma in a man: A case report. J Med Case Reports. 4:3742010. View Article : Google Scholar
26	Serra R, Grande R, Gallelli L, Rende P, Scarcello E, Buffone G, Caliò FG, Gasbarro V, Amato B and de Franciscis S: Carotid body paragangliomas and matrix metalloproteinases. Ann Vasc Surg. 28:1665–1670. 2014. View Article : Google Scholar : PubMed/NCBI
27	Derchi LE, Serafini G, Rabbia C, De Albertis P, Solbiati L, Candiani F, Musante F, Bertoglio C and Rizzatto G: Carotid body tumors: US evaluation. Radiology. 182:457–459. 1992. View Article : Google Scholar : PubMed/NCBI
28	Arslan H, Unal O, Kutluhan A and Sakarya ME: Power Doppler scanning in the diagnosis of carotid body tumors. J Ultrasound Med. 19:367–370. 2000.PubMed/NCBI
29	Giannoni MF, Irace L, Vicenzini E, Massa R, Gossetti B and Benedetti-Valentini F: Carotid body tumors: Advantages of contrast ultrasound investigation. J Neuroimaging. 19:388–390. 2009. View Article : Google Scholar : PubMed/NCBI
30	Liu JK, Sameshima T, Gottfried ON, Couldwell WT and Fukushima T: The combined transmastoid retro- and infralabyrinthine transjugular transcondylar transtubercular high cervical approach for resection of glomus jugulare tumors. Neurosurgery. 59(Suppl 1): S115–S125. 2006.
31	Rosa M and Sahoo S: Bilateral carotid body tumor: The role of fine-needle aspiration biopsy in the preoperative diagnosis. Diagn Cytopathol. 36:178–180. 2008. View Article : Google Scholar : PubMed/NCBI