Adenosquamous carcinoma arising from a thyroglossal duct cyst: A case report

Chang,Yu‑Sung; Su,Hsin‑Hao; Ho,Szu‑Pei

doi:10.3892/ol.2016.4262

Adenosquamous carcinoma arising from a thyroglossal duct cyst: A case report

Authors:
- Yu‑Sung Chang
- Hsin‑Hao Su
- Szu‑Pei Ho
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Affiliations: Department of Otolaryngology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, R.O.C., Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, R.O.C.
Published online on: February 23, 2016 https://doi.org/10.3892/ol.2016.4262
Pages: 2668-2672

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Abstract

The current study describes a case of adenosquamous carcinoma originating from a thyroglossal duct cyst (TGDC). A 7-year-old man presented with an asymptomatic mass in the left mid‑neck, which was soft and mobile on palpation. Fine‑needle aspiration was performed, but cytology did not detect any malignant cells. Computed tomography demonstrated a single cystic lesion in the left lobe of the thyroid gland; therefore, surgery was performed on the suspected thyroid cyst. However, it was identified intraoperatively that the lesion was separated from the thyroid gland and instead adhered to an additional hyoid bone; therefore, the Sistrunk procedure was performed. Histopathological examination of the resected tumor confirmed the diagnosis of adenosquamous carcinoma originating from a TGDC. Carcinoma arising from a TGDC is rare, and accounts for 1% of all TGDC cases. The most common subtype of carcinoma associated with TGDC is papillary carcinoma, whilst adenosquamous carcinoma developing from a TGDC is extremely rare, with only one case currently reported in the literature. Although a consensus for the management of this disease has not yet been established, adequate surgical excision with long‑term follow-up is currently the preferred treatment.

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