Reflectance confocal microscopy and dermoscopy for in vivo, non-invasive skin imaging of superficial basal cell carcinoma

Ghita,Mihaela  A.; Caruntu,Constantin; Rosca,Adrian  E.; Kaleshi,Harillaq; Caruntu,Ana; Moraru,Liliana; Docea,Anca  Oana; Zurac,Sabina; Boda,Daniel; Neagu,Monica; Spandidos,Demetrios  A.; Tsatsakis,Aristidis  M.

doi:10.3892/ol.2016.4354

Reflectance confocal microscopy and dermoscopy for in vivo, non-invasive skin imaging of superficial basal cell carcinoma

Authors:
- Mihaela A. Ghita
- Constantin Caruntu
- Adrian E. Rosca
- Harillaq Kaleshi
- Ana Caruntu
- Liliana Moraru
- Anca Oana Docea
- Sabina Zurac
- Daniel Boda
- Monica Neagu
- Demetrios A. Spandidos
- Aristidis M. Tsatsakis
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Affiliations: Dermatology Research Laboratory, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest 050474, Romania, Department of Physiology, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest 050474, Romania, Department of Dermatology, ‘Prof. N. Paulescu’ National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest 011233, Romania, Department of Oral and Maxillofacial Surgery, ‘Carol Davila’ Central Military Emergency Hospital, Bucharest 010825, Romania, Department of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova 200349, Romania, Department of Pathology, ‘Carol Davila’ University of Medicine and Pharmacy, Colentina University Hospital, Bucharest 020125, Romania, ‘Victor Babes’ National Institute of Pathology, Bucharest 050096, Romania, Laboratory of Clinical Virology, University of Crete Medical School, Heraklion 71409, Greece, Department of Forensic Sciences and Toxicology, Medical School, University of Crete, Heraklion 71003, Greece
Published online on: March 21, 2016 https://doi.org/10.3892/ol.2016.4354
Pages: 3019-3024
Copyright: © Ghita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Superficial basal cell carcinoma (sBCC) is the second most frequent histological type of basal cell carcinoma (BCC), usually requiring a skin biopsy to confirm the diagnosis. It usually appears on the upper trunk and shoulders as erythematous and squamous lesions. Although it has a slow growth and seldom metastasizes, early diagnosis and management are of crucial importance in preventing local invasion and subsequent disfigurement. Dermoscopy is nowadays an indispensable tool for the dermatologist when evaluating skin tumors. Reflectance confocal microscopy (RCM) is a novel imaging technique that allows the non‑invasive, in vivo quasi‑microscopic morphological and dynamic assessment of superficial skin tumors. Moreover, it offers the advantage of performing infinite repeatable determinations to monitor disease progression and non-surgical treatment for sBCC. Herein, we present three lesions of sBCC evaluated using in vivo and non‑invasive imaging techniques, emphasizing the usefulness of combining RCM with dermoscopy for increasing the diagnostic accuracy of sBCC.

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