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Silencing of AP-4 inhibits proliferation, induces cell cycle arrest and promotes apoptosis in human lung cancer cells

  • Authors:
    • Xuanyu Hu
    • Wei Guo
    • Shanshan Chen
    • Yizhuo Xu
    • Ping Li
    • Huaqi Wang
    • Heying Chu
    • Juan Li
    • Yuwen Du
    • Xiaonan Chen
    • Guojun Zhang
    • Guoqiang Zhao

  • View Affiliations

  • Published online on: April 18, 2016     https://doi.org/10.3892/ol.2016.4451
  • Pages: 3735-3742
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Abstract

Activating enhancer-binding protein (AP)-4 is a member of the basic helix-loop-helix transcription factors, and is involved in tumor biology. However, the role of AP‑4 in human lung cancer remains to be fully elucidated. In the present study, the expression of AP‑4 in human lung cancer tissues and cells was investigated by reverse transcription-quantitative polymerase chain reaction, and it was observed that the level of AP‑4 was increased in tumor tissues and cells compared with their normal counterparts. AP‑4 expression was knocked down by transfection with a specific small interfering RNA (siRNA) in lung cancer cells, and this indicated that siRNA‑mediated silencing of AP‑4 inhibited cell proliferation, arrested the cell cycle at the G0/G1 phase and induced apoptosis by modulating the expression of p21 and cyclin D1. The results of the present study suggest that AP‑4 may be an oncoprotein that has a significant role in lung cancer, and that siRNA-mediated silencing of AP‑4 may have therapeutic potential as a strategy for the treatment of lung cancer.
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June-2016
Volume 11 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • Impact Factor: 2.5
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  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
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Spandidos Publications style
Hu X, Guo W, Chen S, Xu Y, Li P, Wang H, Chu H, Li J, Du Y, Chen X, Chen X, et al: Silencing of AP-4 inhibits proliferation, induces cell cycle arrest and promotes apoptosis in human lung cancer cells. Oncol Lett 11: 3735-3742, 2016.
APA
Hu, X., Guo, W., Chen, S., Xu, Y., Li, P., Wang, H. ... Zhao, G. (2016). Silencing of AP-4 inhibits proliferation, induces cell cycle arrest and promotes apoptosis in human lung cancer cells. Oncology Letters, 11, 3735-3742. https://doi.org/10.3892/ol.2016.4451
MLA
Hu, X., Guo, W., Chen, S., Xu, Y., Li, P., Wang, H., Chu, H., Li, J., Du, Y., Chen, X., Zhang, G., Zhao, G."Silencing of AP-4 inhibits proliferation, induces cell cycle arrest and promotes apoptosis in human lung cancer cells". Oncology Letters 11.6 (2016): 3735-3742.
Chicago
Hu, X., Guo, W., Chen, S., Xu, Y., Li, P., Wang, H., Chu, H., Li, J., Du, Y., Chen, X., Zhang, G., Zhao, G."Silencing of AP-4 inhibits proliferation, induces cell cycle arrest and promotes apoptosis in human lung cancer cells". Oncology Letters 11, no. 6 (2016): 3735-3742. https://doi.org/10.3892/ol.2016.4451