Pancreatic hamartoma, a rare benign disease of the pancreas: A case report

Zhang,Jianwei; Wang,Hui; Tang,Xiaolong; Jiang,Qinglong; Wang,Chengfeng

doi:10.3892/ol.2016.4535

Pancreatic hamartoma, a rare benign disease of the pancreas: A case report

Authors:
- Jianwei Zhang
- Hui Wang
- Xiaolong Tang
- Qinglong Jiang
- Chengfeng Wang
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Affiliations: Department of Abdominal Surgery, Chinese Academy of Medical Sciences, Cancer Hospital, Beijing 100021, P.R. China
Published online on: May 6, 2016 https://doi.org/10.3892/ol.2016.4535
Pages: 3925-3928
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic hamartoma is an extremely rare, non-neoplastic, mass-forming lesion that may be mistaken for malignancy, and the pre-operative diagnosis is particularly challenging. The published literature contains only 23 cases of pancreatic hamartoma. The majority of the cases reported patients with a single benign tumor‑like disease that received a pancreatectomy. Immunohistochemical findings confirmed the diagnosis following surgery. The current study reports the case of a 53-year-old female who presented to the Department of Abdominal Surgery, Chinese Academy of Medical Sciences, Cancer Hospital (Beijing, China), due to abdominal pain. Abdominal magnetic resonance imaging revealed a 22x14‑mm mass in the head of the pancreas. The patient was pre-operatively diagnosed with a pancreatic space‑occupying lesion, and subsequently underwent a pancreaticoduodenectomy. The post‑operative course was uneventful. Histological examination of the resected lesion resulted in a diagnosis of pancreatic hamartoma. There were no signs of recurrence at 55 months post-surgery.

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1	Nagata S, Yamaguchi K, Inoue T, Yamaguchi H, Ito T, Gibo J, Tanaka M and Tsuneyoshi M: Solid pancreatic hamartoma. Pathol Int. 57:276–280. 2007. View Article : Google Scholar : PubMed/NCBI
2	Kim HH, Cho CK, Hur YH, Koh YS, Kim JC, Kim HJ, Kim JW, Kim Y and Lee JH: Pancreatic hamartoma diagnosed after surgical resection. J Korean Surg Soc. 83:330–334. 2012. View Article : Google Scholar : PubMed/NCBI
3	Durczynski A, Wiszniewski M, Olejniczak W, Polkowski M, Sporny S and Strzelczyk J: Asymptomatic solid pancreatic hamartoma. Arch Med Sci. 7:1082–1084. 2011. View Article : Google Scholar : PubMed/NCBI
4	Addeo P, Tudor G, Oussoultzoglou E, Averous G and Bachellier P: Pancreatic hamartoma. Surgery. 156:1284–1285. 2014. View Article : Google Scholar : PubMed/NCBI
5	Inoue H, Tameda M, Yamada R, Tano S, Kasturahara M, Hamada Y, Tanaka K, Horiki N and Takei Y: Pancreatic hamartoma: A rare cause of obstructive jaundice. Endoscopy. 46(Suppl 1): 157–158. 2014.
6	Kawakami F, Shimizu M, Yamaguchi H, Hara S, Matsumoto I, Ku Y and Itoh T: Multiple solid pancreatic hamartomas: A case report and review of the literature. World J Gastrointest Oncol. 4:202–206. 2012. View Article : Google Scholar : PubMed/NCBI
7	Anthony PP, Faber RG and Russell RC: Pseudotumours of the pancreas. BMJ. 1:8141977. View Article : Google Scholar : PubMed/NCBI
8	Burt TB, Condon VR and Matlak ME: Fetal pancreatic hamartoma. Pediatr Radiol. 13:287–289. 1983. View Article : Google Scholar : PubMed/NCBI
9	Flaherty MJ and Benjamin DR: Multicystic pancreatic hamartoma: A distinctive lesion with immunohistochemical and ultrastructural study. Hum Pathol. 23:1309–1312. 1992. View Article : Google Scholar : PubMed/NCBI
10	Izbicki JR, Knoefel WT, Müller-Höcker J and Mandelkow HK: Pancreatic hamartoma: A benign tumor of the pancreas. Am J Gastroenterol. 89:1261–1262. 1994.PubMed/NCBI
11	Thrall M, Jessurun J, Stelow EB, Adsay NV, Vickers SM, Whitson AK, Saltzman DA and Pambuccian SE: Multicystic adenomatoid hamartoma of the pancreas: A hitherto undescribed pancreatic tumor occurring in a 3-year-old boy. Pediatr Dev Pathol. 11:314–320. 2008. View Article : Google Scholar : PubMed/NCBI
12	Pauser U, da Silva MT, Placke J, Klimstra DS and Klöppel G: Cellular hamartoma resembling gastrointestinal stromal tumor: A solid tumor of the pancreas expressing c-kit (CD117). Mod Pathol. 18:1211–1216. 2005. View Article : Google Scholar : PubMed/NCBI
13	Pauser U, Kosmahl M, Kruslin B, Klimstra DS and Klöppel G: Pancreatic solid and cystic hamartoma in adults: Characterization of a new tumorous lesion. Am J Surg Pathol. 29:797–800. 2005. View Article : Google Scholar : PubMed/NCBI
14	Heald B, Burke CA, Kalady M and Eng C: ACG guidelines on management of PTEN-hamartoma tumor Ssyndrome: Does the evidence support so much so young? Am J Gastroenterol. 110:1733–1734. 2015. View Article : Google Scholar : PubMed/NCBI
15	Noltenius H and Colmant HJ: Excessive hyperplasia of the exocrine pancreatic tissue and Wernicke's encephalopathy (author's transl). Med Klin. 72:2155–2158. 1977.(In German). PubMed/NCBI
16	Wu SS, Vargas HI and French SW: Pancreatic hamartoma with Langerhans cell histiocytosis in a draining lymph node. Histopathology. 33:485–487. 1998. View Article : Google Scholar : PubMed/NCBI
17	Sampelean D, Adam M, Muntean V, Hanescu B and Domsa I: Pancreatic hamartoma and SAPHO syndrome: A case report. J Gastrointestin Liver Dis. 18:483–486. 2009.PubMed/NCBI
18	Sueyoshi R, Okazaki T, Lane GJ, Arakawa A, Yao T and Yamataka A: Multicystic adenomatoid pancreatic hamartoma in a child: Case report and literature review. Int J Surg Case Rep. 4:98–100. 2013. View Article : Google Scholar : PubMed/NCBI
19	McFaul CD, Vitone LJ, Campbell F, Azadeh B, Hughes ML, Garvey CJ, Ghaneh P, Neoptolemos JP and Longnecker DS: Pancreatic hamartoma. Pancreatology. 4:533–538. 2004. View Article : Google Scholar : PubMed/NCBI
20	Beger HG, Siech M, Poch B, Mayer B and Schoenberg MH: Limited surgery for benign tumours of the pancreas: A systematic review. World J Surg. 39:1557–1566. 2015. View Article : Google Scholar : PubMed/NCBI