Open Access

miR-199a-5p induces cell invasion by suppressing E-cadherin expression in cutaneous squamous cell carcinoma

  • Authors:
    • Shaohua Wang
    • Ke Cao
    • Quanyong He
    • Zhaoqi Yin
    • Jianda Zhou
  • View Affiliations

  • Published online on: May 18, 2016     https://doi.org/10.3892/ol.2016.4602
  • Pages: 97-101
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A growing quantity of evidence exists to suggest that microRNAs are significant regulators of multiple cellular processes. When expressed aberrantly in different types of cancer, including cutaneous squamous cell carcinoma (cSCC), they play key roles in tumorigenesis and progression. The aberrant expression of miR‑199a‑5p has been observed to contribute to carcinogenesis in various types of cancer. However, the role of miR‑199a‑5p in the progression of cSCC metastasis remains largely unknown. In this study, we determined that miR‑199a‑5p was the upstream regulator of CDH1 (E‑cadherin) and that it could suppress the expression of E‑cadherin in cSCC cells. In addition, miR‑199a‑5p mimics significantly induced cell invasion and the activity of matrix metalloproteinase (MMP)2 and MMP9 in cSCC cells. In conclusion, these results are likely to aid in elucidating the molecular mechanisms of cSCC progression. In addition, the findings provide a new theoretical basis to further investigate miR‑199a‑5p as a potential biomarker and a promising approach in cSCC treatment.
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July-2016
Volume 12 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang S, Cao K, He Q, Yin Z and Zhou J: miR-199a-5p induces cell invasion by suppressing E-cadherin expression in cutaneous squamous cell carcinoma. Oncol Lett 12: 97-101, 2016.
APA
Wang, S., Cao, K., He, Q., Yin, Z., & Zhou, J. (2016). miR-199a-5p induces cell invasion by suppressing E-cadherin expression in cutaneous squamous cell carcinoma. Oncology Letters, 12, 97-101. https://doi.org/10.3892/ol.2016.4602
MLA
Wang, S., Cao, K., He, Q., Yin, Z., Zhou, J."miR-199a-5p induces cell invasion by suppressing E-cadherin expression in cutaneous squamous cell carcinoma". Oncology Letters 12.1 (2016): 97-101.
Chicago
Wang, S., Cao, K., He, Q., Yin, Z., Zhou, J."miR-199a-5p induces cell invasion by suppressing E-cadherin expression in cutaneous squamous cell carcinoma". Oncology Letters 12, no. 1 (2016): 97-101. https://doi.org/10.3892/ol.2016.4602