1
|
Torre LA, Bray F, Siegel RL, Ferlay J,
Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA
Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI
|
2
|
Bosch FX, Ribes J, Diaz M and Cléries R:
Primary liver cancer: Worldwide incidence and trends.
Gastroenterology. 127(5 Suppl 1): S5–S16. 2004. View Article : Google Scholar : PubMed/NCBI
|
3
|
Ferenci P, Fried M, Labrecque D, Bruix J,
Sherman M, Omata M, Heathcote J, Piratsivuth T, Kew M, Otegbayo JA,
et al: World gastroenterology organisation guideline.
Hepatocellular carcinoma (HCC): A global perspective. J
Gastrointestin Liver Dis. 19:311–317. 2010.PubMed/NCBI
|
4
|
Thomas MB and Abbruzzese JL: Opportunities
for targeted therapies in hepatocellular carcinoma. J Clin Oncol.
23:8093–8108. 2005. View Article : Google Scholar : PubMed/NCBI
|
5
|
Signoriello S, Annunziata A, Lama N,
Signoriello G, Chiodini P, De Sio I, Daniele B, Di Costanzo GG,
Calise F, Olivieri G, et al: Survival after locoregional treatments
for hepatocellular carcinoma: A cohort study in real-world
patients. Scientific World Journal. 2012:5647062012. View Article : Google Scholar : PubMed/NCBI
|
6
|
Chan SL and Yeo W: Targeted therapy of
hepatocellular carcinoma: Present and future. J Gastroenterol
Hepatol. 27:862–872. 2012. View Article : Google Scholar : PubMed/NCBI
|
7
|
Lu SC: Where are we in the chemoprevention
of hepatocellular carcinoma? Hepatology. 51:734–736.
2010.PubMed/NCBI
|
8
|
Chen XP, He SQ, Zhao X, Huang ZY and Li
CH: Chinese medicine Extractum trametes robiniophila murr augment
tumor necrosis factor related apoptosis-inducing ligand induced
apoptosis in human hepatic cancer cell lines. Zhonghua Wai Ke Za
Zhi. 43:1524–1527. 2005.(In Chinese). PubMed/NCBI
|
9
|
Zhang N, Kong X, Yan S, Yuan C and Yang Q:
Huaier aqueous extract inhibits proliferation of breast cancer
cells by inducing apoptosis. Cancer Sci. 101:2375–2383. 2010.
View Article : Google Scholar : PubMed/NCBI
|
10
|
Wang X, Zhang N, Huo Q, Sun M, Dong L,
Zhang Y, Xu G and Yang Q: Huaier aqueous extract inhibits stem-like
characteristics of MCF7 breast cancer cells via inactivation of
hedgehog pathway. Tumour Biol. 35:10805–10813. 2014. View Article : Google Scholar : PubMed/NCBI
|
11
|
Ren J, Zheng C, Feng G, Liang H, Xia X,
Fang J, Duan X and Zhao H: Inhibitory effect of extract of fungi of
Huaier on hepatocellular carcinoma cells. J Huazhong Univ Sci
Technolog Med Sci. 29:198–201. 2009. View Article : Google Scholar : PubMed/NCBI
|
12
|
Zheng J, Li C, Wu X, Liu M, Sun X, Yang Y,
Hao M, Sheng S, Sun Y, Zhang H, et al: Huaier polysaccharides
suppresses hepatocarcinoma MHCC97-H cell metastasis via
inactivation of EMT and AEG-1 pathway. Int J Biol Macromol.
64:106–110. 2014. View Article : Google Scholar : PubMed/NCBI
|
13
|
Zheng J, Li C, Wu X, Liu M, Sun X, Yang Y,
Hao M, Sheng S, Sun Y, Zhang H, et al: Astrocyte elevated gene-1
(AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced
anti-metastatic potency via inactivating downstream P13K/Akt
pathway as well as augmenting cell-mediated immune response. Tumour
Biol. 35:4219–4224. 2014. View Article : Google Scholar : PubMed/NCBI
|
14
|
Li C, Wu X, Zhang H, Yang G, Hao M, Sheng
S, Sun Y, Long J, Hu C, Sun X, et al: A Huaier polysaccharide
inhibits hepatocellular carcinoma growth and metastasis. Tumour
Biol. 36:1739–1745. 2015. View Article : Google Scholar : PubMed/NCBI
|
15
|
Wu T, Chen W, Liu S, Lu H, Wang H, Kong D,
Huang X, Kong Q, Ning Y and Lu Z: Huaier suppresses proliferation
and induces apoptosis in human pulmonary cancer cells via
upregulation of miR-26b-5p. FEBS Lett. 588:2107–2114. 2014.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Yan X, Lyu T, Jia N, Yu Y, Hua K and Feng
W: Huaier aqueous extract inhibits ovarian cancer cell motility via
the AKT/GSK3β/β-catenin pathway. PLoS One. 8:e637312013. View Article : Google Scholar : PubMed/NCBI
|
17
|
Li C, Wu X, Zhang H, Yang G, Hao M, Sheng
S, Sun Y, Long J, Hu C, Sun X, et al: A Huaier polysaccharide
restrains hepatocellular carcinoma growth and metastasis by
suppression angiogenesis. Int J Biol Macromol. 75:115–120. 2015.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Wang X, Zhang N, Huo Q and Yang Q:
Anti-angiogenic and antitumor activities of Huaier aqueous extract.
Oncol Rep. 28:1167–1175. 2012.PubMed/NCBI
|
19
|
Xu X, Wei Q, Wang K, Ling Q, Xie H, Zhou L
and Zheng S: Anticancer effects of Huaier are associated with
down-regulation of P53. Asian Pac J Cancer Prev. 12:2251–2254.
2011.PubMed/NCBI
|
20
|
Chang L and Karin M: Mammalian MAP kinase
signalling cascades. Nature. 410:37–40. 2001. View Article : Google Scholar : PubMed/NCBI
|
21
|
Burotto M, Chiou VL, Lee JM and Kohn EC:
The MAPK pathway across different malignancies: A new perspective.
Cancer. 120:3446–3456. 2014. View Article : Google Scholar : PubMed/NCBI
|
22
|
Haakenson J, Wu JY, Xiang S, Williams KA,
Bai W and Zhang X: HDAC6-Dependent functions in tumor cells:
Crossroad with the MAPK Pathways. Crit Rev Oncog. 20:65–81. 2015.
View Article : Google Scholar : PubMed/NCBI
|
23
|
Luo Z, Yu G, Lee HW, Li L, Wang L, Yang D,
Pan Y, Ding C, Qian J, Wu L, et al: The Nedd8-activating enzyme
inhibitor MLN4924 induces autophagy and apoptosis to suppress liver
cancer cell growth. Cancer Res. 72:3360–3371. 2012. View Article : Google Scholar : PubMed/NCBI
|
24
|
Casimiro MC, Velasco-Velázquez M,
Aguirre-Alvarado C and Pestell RG: Overview of cyclins D1 function
in cancer and the CDK inhibitor landscape: Past and present. Expert
Opin Investig Drugs. 23:295–304. 2014. View Article : Google Scholar : PubMed/NCBI
|
25
|
Pestell RG: New roles of cyclin D1. Am J
Pathol. 183:3–9. 2013. View Article : Google Scholar : PubMed/NCBI
|
26
|
Rathmell JC and Thompson CB: The central
effectors of cell death in the immune system. Annu Rev Immunol.
17:781–828. 1999. View Article : Google Scholar : PubMed/NCBI
|
27
|
Hsieh SC, Huang MH, Cheng CW, Hung JH,
Yang SF and Hsieh YH: α-Mangostin induces mitochondrial dependent
apoptosis in human hepatoma SK-Hep-1 cells through inhibition of
p38 MAPK pathway. Apoptosis. 18:1548–1560. 2013. View Article : Google Scholar : PubMed/NCBI
|
28
|
Lamy E, Herz C, Lutz-Bonengel S, Hertrampf
A, Márton MR and Mersch-Sundermann V: The MAPK pathway signals
telomerase modulation in response to isothiocyanate-induced DNA
damage of human liver cancer cells. PLoS One. 8:e532402013.
View Article : Google Scholar : PubMed/NCBI
|
29
|
Chiba T, Suzuki E, Yuki K, Zen Y, Oshima
M, Miyagi S, Saraya A, Koide S, Motoyama T, Ogasawara S, et al:
Disulfiram eradicates tumor-initiating hepatocellular carcinoma
cells in ROS-p38 MAPK pathway-dependent and -independent manners.
PLoS One. 9:e848072014. View Article : Google Scholar : PubMed/NCBI
|
30
|
Jiang Q, Li F, Shi K, Wu P, An J, Yang Y
and Xu C: ATF4 activation by the p38MAPK-eIF4E axis mediates
apoptosis and autophagy induced by selenite in Jurkat cells. FEBS
Lett. 587:2420–2429. 2013. View Article : Google Scholar : PubMed/NCBI
|
31
|
Taylor CA, Zheng Q, Liu Z and Thompson JE:
Role of p38 and JNK MAPK signaling pathways and tumor suppressor
p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung
cancer cells. Mol Cancer. 12:352013. View Article : Google Scholar : PubMed/NCBI
|
32
|
Hui K, Yang Y, Shi K, Luo H, Duan J, An J,
Wu P, Ci Y, Shi L and Xu C: The p38 MAPK-regulated PKD1/CREB/Bcl-2
pathway contributes to selenite-induced colorectal cancer cell
apoptosis in vitro and in vivo. Cancer Lett. 354:189–199. 2014.
View Article : Google Scholar : PubMed/NCBI
|
33
|
Zhang X, Bi L, Ye Y and Chen J:
Formononetin induces apoptosis in PC-3 prostate cancer cells
through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt
pathway. Nutr Cancer. 66:656–661. 2014. View Article : Google Scholar : PubMed/NCBI
|
34
|
Hengartner MO: The biochemistry of
apoptosis. Nature. 407:770–776. 2000. View
Article : Google Scholar : PubMed/NCBI
|
35
|
Mayo LD and Donner DB: The PTEN, Mdm2, p53
tumor suppressor-oncoprotein network. Trends Biochem Sci.
27:462–467. 2002. View Article : Google Scholar : PubMed/NCBI
|
36
|
Li F, Ambrosini G, Chu EY, Plescia J,
Tognin S, Marchisio PC and Altieri DC: Control of apoptosis and
mitotic spindle checkpoint by survivin. Nature. 396:580–584. 1998.
View Article : Google Scholar : PubMed/NCBI
|
37
|
Fernández JG, Rodriguez DA, Valenzuela M,
Calderon C, Urzúa U, Munroe D, Rosas C, Lemus D, Díaz N, Wright MC,
et al: Survivin expression promotes VEGF-induced tumor angiogenesis
via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription.
Mol Cancer. 13:2092014. View Article : Google Scholar : PubMed/NCBI
|