MYEOV gene overexpression in primary plasma cell leukemia with t(11;14)(q13;q32)

  • Authors:
    • Nicoletta Coccaro
    • Giuseppina Tota
    • Luisa Anelli
    • Antonella Zagaria
    • Paola Casieri
    • Angelo Cellamare
    • Crescenzio Francesco Minervini
    • Angela Minervini
    • Cosimo Cumbo
    • Luciana Impera
    • Claudia Brunetti
    • Paola Orsini
    • Elisa Parciante
    • Anna Mestice
    • Giorgina Specchia
    • Francesco Albano
  • View Affiliations

  • Published online on: June 22, 2016     https://doi.org/10.3892/ol.2016.4759
  • Pages: 1460-1464
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Abstract

Primary plasma cell leukemia (pPCL) is an uncommon form of plasma cell dyscrasia, and the most aggressive of the human monoclonal gammopathies. The t(11;14)(q13;q32) rearrangement is the most common alteration in pPCL, promoting cyclin D1 (CCND1) gene overexpression caused by its juxtaposition with the immunoglobulin heavy locus chromosome region. The myeloma overexpressed (MYEOV) gene maps very close to the CCND1 gene on chromosome 11, but its overexpression is rarely observed in multiple myeloma. The present study describes a case of pPCL with t(11;14) characterized by a breakpoint on der(11), unlike the one usually observed. Droplet digital polymerase chain reaction analysis revealed overexpression of CCND1 and MYEOV. To the best of our knowledge, MYEOV gene overexpression has never been previously described in pPCL.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Coccaro N, Tota G, Anelli L, Zagaria A, Casieri P, Cellamare A, Minervini CF, Minervini A, Cumbo C, Impera L, Impera L, et al: MYEOV gene overexpression in primary plasma cell leukemia with t(11;14)(q13;q32). Oncol Lett 12: 1460-1464, 2016.
APA
Coccaro, N., Tota, G., Anelli, L., Zagaria, A., Casieri, P., Cellamare, A. ... Albano, F. (2016). MYEOV gene overexpression in primary plasma cell leukemia with t(11;14)(q13;q32). Oncology Letters, 12, 1460-1464. https://doi.org/10.3892/ol.2016.4759
MLA
Coccaro, N., Tota, G., Anelli, L., Zagaria, A., Casieri, P., Cellamare, A., Minervini, C. F., Minervini, A., Cumbo, C., Impera, L., Brunetti, C., Orsini, P., Parciante, E., Mestice, A., Specchia, G., Albano, F."MYEOV gene overexpression in primary plasma cell leukemia with t(11;14)(q13;q32)". Oncology Letters 12.2 (2016): 1460-1464.
Chicago
Coccaro, N., Tota, G., Anelli, L., Zagaria, A., Casieri, P., Cellamare, A., Minervini, C. F., Minervini, A., Cumbo, C., Impera, L., Brunetti, C., Orsini, P., Parciante, E., Mestice, A., Specchia, G., Albano, F."MYEOV gene overexpression in primary plasma cell leukemia with t(11;14)(q13;q32)". Oncology Letters 12, no. 2 (2016): 1460-1464. https://doi.org/10.3892/ol.2016.4759