Open Access

Survivin and giliomas: A literature review

  • Authors:
    • Rosilin Kotakkathu Varughese
    • Sverre Helge Torp
  • View Affiliations

  • Published online on: July 15, 2016     https://doi.org/10.3892/ol.2016.4867
  • Pages: 1679-1686
  • Copyright: © Varughese et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gliomas are the most common primary brain tumor, the diagnosis of which is challenging. In this respect, the use of immunohistochemical proliferation markers may aid diagnosis; survivin, also known as Baculoviral IAP Repeat Containing 5, is one such marker. Survivin is a unique member of the inhibitors of apoptosis protein gene family, and is known for its dual function as an apoptosis inhibitor and mitosis regulator. Furthermore, survivin has been demonstrated to be overexpressed in a number of malignancies. The purpose of the present literature review was to gain an overview of studies published on the diagnostic and/or prognostic use of survivin in gliomas. Using PubMed, 19 studies matching the inclusion criteria were ultimately included in the present review. The majority of the studies identified revealed that survivin was significantly associated with other proliferation markers, histological malignancy grade, and inversely associated with prognosis. However, there were a number of inconsistencies between studies, which suggests a requirement for standardization of immunohistochemical procedures.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Varughese RK and Torp SH: Survivin and giliomas: A literature review. Oncol Lett 12: 1679-1686, 2016.
APA
Varughese, R.K., & Torp, S.H. (2016). Survivin and giliomas: A literature review. Oncology Letters, 12, 1679-1686. https://doi.org/10.3892/ol.2016.4867
MLA
Varughese, R. K., Torp, S. H."Survivin and giliomas: A literature review". Oncology Letters 12.3 (2016): 1679-1686.
Chicago
Varughese, R. K., Torp, S. H."Survivin and giliomas: A literature review". Oncology Letters 12, no. 3 (2016): 1679-1686. https://doi.org/10.3892/ol.2016.4867