IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling

  • Authors:
    • Nan Zhou
    • Fuding Lu
    • Cheng Liu
    • Kewei Xu
    • Jian Huang
    • Dexin Yu
    • Liangkuan Bi
  • View Affiliations

  • Published online on: July 21, 2016     https://doi.org/10.3892/ol.2016.4900
  • Pages: 1915-1920
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Abstract

The epithelial-mesenchymal transition (EMT) process has increasingly been examined due to its role in the progression of human tumors. Renal cell carcinoma (RCC) is one of the most common urological tumors that results in patient mortality. Previous studies have demonstrated that the EMT process is closely associated with the metastasis of RCC; however, the underlying molecular mechanism has not been determined yet. The present study revealed that interleukin (IL)‑8 was highly expressed in metastatic RCC. IL-8 could induce the EMT of an RCC cell line by enhancing N‑cadherin expression and decreasing E‑cadherin expression. Furthermore, IL‑8 could induce AKT phosphorylation, and the phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitor LY294002 could inhibit the EMT of RCC cells that was induced by IL‑8. Therefore, these results suggest that IL‑8 is able to promote the EMT of RCC through the activation of the AKT signal transduction pathway, and this may provide a possible molecular mechanism for RCC metastasis.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou N, Lu F, Liu C, Xu K, Huang J, Yu D and Bi L: IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling. Oncol Lett 12: 1915-1920, 2016
APA
Zhou, N., Lu, F., Liu, C., Xu, K., Huang, J., Yu, D., & Bi, L. (2016). IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling. Oncology Letters, 12, 1915-1920. https://doi.org/10.3892/ol.2016.4900
MLA
Zhou, N., Lu, F., Liu, C., Xu, K., Huang, J., Yu, D., Bi, L."IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling". Oncology Letters 12.3 (2016): 1915-1920.
Chicago
Zhou, N., Lu, F., Liu, C., Xu, K., Huang, J., Yu, D., Bi, L."IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling". Oncology Letters 12, no. 3 (2016): 1915-1920. https://doi.org/10.3892/ol.2016.4900