Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation

  • Authors:
    • Xiaobin Chang
    • Jimin Zhao
    • Fang Tian
    • Yanan Jiang
    • Jing Lu
    • Junfen Ma
    • Xiaoyan Zhang
    • Guoguo Jin
    • Youtian Huang
    • Zigang Dong
    • Kangdong Liu
    • Ziming Dong
  • View Affiliations

  • Published online on: July 25, 2016     https://doi.org/10.3892/ol.2016.4910
  • Pages: 2232-2238
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Abstract

Aberrant AKT and extracellular signal-regulated kinase (ERK) activation is often observed in various human cancers. Both AKT and ERK are important in the phosphoinositide 3-kinase/AKT and mitogen-activated protein kinase kinase/ERK signaling pathways, which play vital roles in cell proliferation, differentiation and survival. Compounds that are able to block these pathways have therefore a promising use in cancer treatment and prevention. The present study revealed that AKT and ERK are activated in esophageal cancer TE1 cells. Aloe‑emodin, an anthraquinone present in aloe latex, can suppress TE1 cell proliferation and anchor‑independent cell growth. Aloe‑emodin can also reduce the number of TE1 cells in S phase. Protein analysis indicated that aloe‑emodin inhibits the phosphorylation of AKT and ERK in a dose‑dependent manner. Overall, the present data indicate that aloe‑emodin can suppress TE1 cell growth by inhibiting AKT and ERK phosphorylation, and suggest its clinical use for cancer therapy.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chang X, Zhao J, Tian F, Jiang Y, Lu J, Ma J, Zhang X, Jin G, Huang Y, Dong Z, Dong Z, et al: Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation. Oncol Lett 12: 2232-2238, 2016
APA
Chang, X., Zhao, J., Tian, F., Jiang, Y., Lu, J., Ma, J. ... Dong, Z. (2016). Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation. Oncology Letters, 12, 2232-2238. https://doi.org/10.3892/ol.2016.4910
MLA
Chang, X., Zhao, J., Tian, F., Jiang, Y., Lu, J., Ma, J., Zhang, X., Jin, G., Huang, Y., Dong, Z., Liu, K., Dong, Z."Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation". Oncology Letters 12.3 (2016): 2232-2238.
Chicago
Chang, X., Zhao, J., Tian, F., Jiang, Y., Lu, J., Ma, J., Zhang, X., Jin, G., Huang, Y., Dong, Z., Liu, K., Dong, Z."Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation". Oncology Letters 12, no. 3 (2016): 2232-2238. https://doi.org/10.3892/ol.2016.4910