Open Access

Caveolin‑1 is overexpressed in hypopharyngeal squamous cell carcinoma and correlates with clinical parameters

  • Authors:
    • Xuening Zhao
    • Gang Yu
    • Xuemin Yu
    • Juan Wang
    • Xinliang Pan
  • View Affiliations

  • Published online on: August 5, 2016     https://doi.org/10.3892/ol.2016.4963
  • Pages: 2371-2374
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to identify the role of caveolin‑1 (CAV1) in hypopharyngeal squamous cell carcinoma (HSCC) and identify its possible correlation with tumor clinical parameters. Expression of CAV1 was measured using immunohistochemical staining of 66 HSCC samples and 44 samples from morphologically normal tissues adjacent to the carcinomas. Expression of CAV1 in HSCC and paracancerous tissues were 71.2 and 9.5% respectively. Levels of CAV1 expression were significantly associated with tumor differentiation, tumor‑node‑metastasis stage and lymph nodes metastasis (P<0.05). The present study identified that expression of CAV1 in HSCC is significantly higher than in paracancerous tissues, suggesting that this high expression of CAV1 is associated with tumor invasion and metastasis.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao X, Yu G, Yu X, Wang J and Pan X: Caveolin‑1 is overexpressed in hypopharyngeal squamous cell carcinoma and correlates with clinical parameters. Oncol Lett 12: 2371-2374, 2016.
APA
Zhao, X., Yu, G., Yu, X., Wang, J., & Pan, X. (2016). Caveolin‑1 is overexpressed in hypopharyngeal squamous cell carcinoma and correlates with clinical parameters. Oncology Letters, 12, 2371-2374. https://doi.org/10.3892/ol.2016.4963
MLA
Zhao, X., Yu, G., Yu, X., Wang, J., Pan, X."Caveolin‑1 is overexpressed in hypopharyngeal squamous cell carcinoma and correlates with clinical parameters". Oncology Letters 12.4 (2016): 2371-2374.
Chicago
Zhao, X., Yu, G., Yu, X., Wang, J., Pan, X."Caveolin‑1 is overexpressed in hypopharyngeal squamous cell carcinoma and correlates with clinical parameters". Oncology Letters 12, no. 4 (2016): 2371-2374. https://doi.org/10.3892/ol.2016.4963