Open Access

Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients

  • Authors:
    • Katarina Kalavska
    • Michal Chovanec
    • Miriam Zatovicova
    • Martina Takacova
    • Paulina Gronesova
    • Daniela Svetlovska
    • Magdalena Baratova
    • Vera Miskovska
    • Jana Obertova
    • Patrik Palacka
    • Jan Rajec
    • Zuzana Sycova‑Mila
    • Zuzana Cierna
    • Karol Kajo
    • Stanislav Spanik
    • Pavel Babal
    • Jozef Mardiak
    • Silvia Pastorekova
    • Michal Mego
  • View Affiliations

  • Published online on: August 16, 2016     https://doi.org/10.3892/ol.2016.5010
  • Pages: 2590-2598
  • Copyright: © Kalavska et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite the fact that testicular germ cell tumors (TGCTs) are one of the most chemosensitive solid tumors, a small proportion of patients fail to be cured following cisplatin‑based first line chemotherapy. Upregulation of carbonic anhydrase IX (CA IX) in various solid tumors is associated with poor outcome. The current prospective study investigated the prognostic value of serum CA IX level in TGCTs. In total, 83 patients (16 non‑metastatic following orchiectomy with no evidence of disease, 57 metastatic chemotherapy‑naïve and 10 metastatic relapsed chemotherapy‑pretreated) starting adjuvant and/or new line of chemotherapy and 35 healthy controls were enrolled in the study. Serum CA IX values were determined using an enzyme‑linked immunosorbent assay, and intratumoral CA IX was analyzed by immunohistochemistry. Metastatic chemotherapy‑naïve patients had significantly higher mean CA IX serum levels than healthy controls (490.6 vs. 249.6 pg/ml, P=0.005), while there was no difference in serum CA IX levels in non‑metastatic or relapsed TGCT patients compared with healthy controls. There was no significant difference in the mean serum CA IX levels between different groups of patients and between the first and second cycle of chemotherapy, nor association with patients/tumor characteristics. Serum CA IX was not prognostic for progression‑free survival [hazard ratio (HR)=0.81, P=0.730] or overall survival (HR=0.64, P=0.480). However, there was a significant association between intratumoral CA IX expression and serum CA IX concentration (rho=0.51, P=0.040). These results suggest that serum CA IX level correlates with tumor CA IX expression in TGCT patients, but fails to exhibit either a prognostic value or an association with patients/tumor characteristics.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kalavska K, Chovanec M, Zatovicova M, Takacova M, Gronesova P, Svetlovska D, Baratova M, Miskovska V, Obertova J, Palacka P, Palacka P, et al: Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients. Oncol Lett 12: 2590-2598, 2016.
APA
Kalavska, K., Chovanec, M., Zatovicova, M., Takacova, M., Gronesova, P., Svetlovska, D. ... Mego, M. (2016). Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients. Oncology Letters, 12, 2590-2598. https://doi.org/10.3892/ol.2016.5010
MLA
Kalavska, K., Chovanec, M., Zatovicova, M., Takacova, M., Gronesova, P., Svetlovska, D., Baratova, M., Miskovska, V., Obertova, J., Palacka, P., Rajec, J., Sycova‑Mila, Z., Cierna, Z., Kajo, K., Spanik, S., Babal, P., Mardiak, J., Pastorekova, S., Mego, M."Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients". Oncology Letters 12.4 (2016): 2590-2598.
Chicago
Kalavska, K., Chovanec, M., Zatovicova, M., Takacova, M., Gronesova, P., Svetlovska, D., Baratova, M., Miskovska, V., Obertova, J., Palacka, P., Rajec, J., Sycova‑Mila, Z., Cierna, Z., Kajo, K., Spanik, S., Babal, P., Mardiak, J., Pastorekova, S., Mego, M."Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients". Oncology Letters 12, no. 4 (2016): 2590-2598. https://doi.org/10.3892/ol.2016.5010